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《Acta Zoologica Sinica》 2007-06
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Effects of cadmium on hepatopancreatic antioxidant enzyme activity in a freshwater crab Sinopotamon yangtsekiense

YAN Bo, WANG Lan , LI Yong-Quan, LIU Na, WANG QianCollege of Life Science and Technology, Shanxi University, Taiyuan 030006, China  
To explore the effects of cadmium (Cd 2+ ) exposure on the antioxidant enzyme activity of the hepatapancreas, freshwater crabs Sinopotamon yangtsekiense were exposed to Cd 2+ (7.25 mg/L, 14.5 mg/L, 29 mg/L, 58 mg/L, 116 mg/L) for 24, 48, 72 and 96 hours. The activities of antioxidant enzymes were investigated including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), GSSG-reductase (GR) and glutathione S-transferase (GST), and the GPX/SOD, GR/GPX, CAT/SOD ratios, as indicators of antioxidant properties. Results showed that the activities of SOD, CAT and GPX increased initially and decreased subsequently, but GR and GST activities remained almost unchanged. The changes in antioxidant ratios of GPX/SOD, GR/GPX and CAT/SOD indicated that, following the increase of concentration of Cd 2+ and duration of treatment, significant cellular injuries were caused in the hepatapancreas of S.yangtsekiense due to the oxidative stress. We conclude that the changes of the indicators (SOD, CAT, GPX as well as GPX/SOD, GR/GPX, CAT/SOD ratios) may exquisitely reflect the oxidative stress in an aquatic animal induced by Cd 2+ and the toxicity of it.
【Fund】: 国家自然科学基金资助项目(30570194);; 山西省自然科学基金资助项目(20041082)~~
【CateGory Index】: X174
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