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Review on the Toxicological Effect and the Mechanism of Nickel to the Human Health

Wei Youhuan,Huang Qiuchan,Su Xiufang(Department of Chemistry and Biology Engineering,Nanning Teachers College,Longzhou 532400,China)  
Nickel is the essential element of life,however,excessive nickel will be caused harm to the body.In this review the toxicity and its mechanism of nickel to the human health were be summarized.Nickel can cause inflammation,cancer,neurasthenia,system disorders,and lower fertility,teratogenic and mutagenic,and other aspects of nickel outlined the hazards to human health effects.And nickel from the impact of genetic material can be synthesized,the impact of a variety of enzymes in the glands and the role of cause gene mutation,gene loss,gene amplification,a "nickel means" to form Ni2+-peptide complexes,induced by reactive oxygen species and ion in the electrolyte affect content and on the nickel from various harmful to human health effects of the mechanism,based decisions would be made for the toxicological effect of checking heavy metal to the human health of setting with the resuits of this review.
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