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《Journal of North Pharmacy》 2013-06
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盐酸小檗碱对多因素联合诱导人脐静脉血管内皮细胞损伤的调控作用

Objective:To observe the regulation effect of berberine hydrochloride on glucose,insulin,oxidized low density lipoprotein induced by umbilical vein endothelial cell injury in human.Methods:Cultured and passaged in vitro in human umbilical vein endothelial cell line,through the establishment of the normal group,model group,the control group and the treatment of the 1~5 group experiments,cell activity was measured in each group(CCK-8) and cell viability was examined.Results:Treatment groups and Captopril group can significantly improve the activity of endothelial cells and show a certain degree of dose-dependent.The dose treatment group and model group were statistically significant differences(P0.01).Conclusion:The Ber had the determinate protective function to the HUVEC Injured by Glucose,Insulin,and oxidized low-Denslty Lipoprotein.
【Fund】: 四川省卫生厅科研基金资助项目编号:050102
【CateGory Index】: R96
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