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《Journal of North Pharmacy》 2013-06
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Objective:To observe the regulation effect of berberine hydrochloride on glucose,insulin,oxidized low density lipoprotein induced by umbilical vein endothelial cell injury in human.Methods:Cultured and passaged in vitro in human umbilical vein endothelial cell line,through the establishment of the normal group,model group,the control group and the treatment of the 1~5 group experiments,cell activity was measured in each group(CCK-8) and cell viability was examined.Results:Treatment groups and Captopril group can significantly improve the activity of endothelial cells and show a certain degree of dose-dependent.The dose treatment group and model group were statistically significant differences(P0.01).Conclusion:The Ber had the determinate protective function to the HUVEC Injured by Glucose,Insulin,and oxidized low-Denslty Lipoprotein.
【Fund】: 四川省卫生厅科研基金资助项目编号:050102
【CateGory Index】: R96
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