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《Journal of North Pharmacy》 2018-11
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Analysis of the recurrence rate of hyperthyroidism after anti-thyroid drug therapy in graves patients with different activity of TSH receptor antibody

Feng Aihua;Li Haifeng;Mai Xianqiang;Department of Endocrinology,Shunde District;Foshan Shunde District New Rong Qi Hospital general surgery;  
Objective:To study the difference of the recurrence rate of hyperthyroidism in graves patients with different activity of TSH receptor antibody(TRAB)after anti-thyroid drugs. Methods:100 cases of graves patients admitted to our hospital from March 2015 to May 2017 were randomly taken into the discussion,the thyroid index,anti thyroid peroxidase antibody(tpo-ab),anti thyroid globulin antibody(TG-AB)and Trab were measured. According to the first trab of different drops of group,low active group(56 cases),active group(31 cases),High active group(13 cases). Patients were treated with anti-thyroid drugs,until the Trab index turned yin after stopping the drug and observation,records compare hyperthyroidism recurrence rate. Results:the indexes of TPO-Ab,TG-Ab,FT4,FT3 and TSH were compared between the three groups before treatment. The high activity group TRAb,TPO-Ab,TG-Ab,FT4 and FT3 were higher than those of the middle activity group and the low activity group,and P 0.05,compared with the three groups of the index. After treatment,the three groups of TRAb indexes were compared. The high activity group was higher than the medium active group and the low activity group,and the active group was also higher than the low active group,and the activity group was also higher than the low active group,and P0.05. The TPO-Ab index of the high active group was also higher than that of the middle active group and the low active group,and P0.05. The recurrence rate of the disease in the high activity group was 38.46% higher than that in the middle active group 12.90%,the low activity group 7.14%,the medium active group 12.90% was higher than the low activity group7.14%,and P0.05. Conclusion:the TRAb index can not only reflect the condition of Graves more accurately,but also can be used to determine the recurrence of the disease. TRAb high activity Graves disease patients after receiving antithyroid drugs treatment,the disease recurrence rate is higher than those with low activity and activity. Therefore,in clinical treatment,we need to prolong the treatment course of highly active patients.
【CateGory Index】: R581.1
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