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Studies on Physiological Mechanism of Rhubarb Tan to Weight Loss of Experimental Animal

Sun Xia,Liang Guoqing,Li Jicheng△ ,etal Zhejiang Provincial H angzhou Medical H igher Professional School (3 1 0 0 1 2 )△Zhejiang University  
Objective:To investigate the physiologicalmechanism of weightloss of tan in Rhubarb.Method and Result:(1 ) Endogastric administration of tan-extracted Rhubarb had no effecton gastric emptying and pancreatic enzyme secretion,buthepatic-bile secretion was increased.(2 ) Both i.p.and i.v.administration of gallicacid inhibited pancreatic enzyme secretion.Conclusion: Tan in Rhubarb can inhabitgastricemptying and reducepancreaticenzyme secretion.Tan-extracted Rhubarb can increasehepatic bile secretion and has no effect on weight loss.The effect of weight loss is related to the inhabiting of gastric emptying and pancreatic enzyme secretion reducing and hepaticbile secretion increasing.
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