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《Journal of Zhejiang College of Tcm》 2001-05
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The Experimental Research of Antiherpes Simplex Virus Type-2 Effects of Total Saponins in the Root of Astragalus Membranaceus

Wang Zhijie Huang Tieniu Liu Yanwen et al Medical College of Wuhan University(430071)△Zhongnan University of Economics and Law  
In order to understand and exploit the antiviral properties of Astragalus membranaceus,we carried out this research.Methods We use ACV as positive control of antiherpes,through plaque reduction assay and inhibitions of cellular pathological effects of herpes simplex virus type-2,observe the effects of antiherpes of total saponins of Astragalus membranaceus.Results In Hep-2 cell system,the median effective doses(ED50) of ACV of direct virucidal activity,the inhibition effects on the multiplication and infection of HSV-2 333 strain are 16 45ug/ml,18 62 ug/ml,2 7ug/ml,2 73ug/ml separately.Conclusion The treatment indices(TI) of total saponins to HSV-2 333 strain are 2 31,0 96,1 64 times of ACV Tis,it should be worth exploitation.
【Fund】: 湖北省自然科学基金资助 (编号 980 5 90 )
【CateGory Index】: R285.5
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