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《Journal of Zhejiang College of Tcm》 2003-01
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Henostatic Studies on AntiˉHypertension Effect of Xueling

Lv Guiyuan,Chen Suhong △ ,Lv huangjun,et al Zhejiang College of TCM,Hangzhou(310053)△Shanghai University of TCM  
Objective:To confirmthe antiˉhypertension effect of Xueling.Methods:Fromthe reducing blood pressure experiment on Wister rats and SHR(spontaneity hypertension rats),we observe the influence on blood pressure and heart rate after taking different doses by ig or iv.Results:The three doses of Xueling being taken by injecting vessel(0.25g/kg,0.38g/kg,0.50g/kg)or by ig(0.5g/kg,1.0g/kg,2.0g/kg)have the obvious effect on reducing blood pressure with certain dosageˉeffect relation,while there is no influence on heart rate.After being taken once by ig,Xueling takes effect on antiˉhypertension in1hour,takes the maxium effect in2hours and lasts6hours,the effects last14days after being taken conˉtinuous doses.There is the same effect on Beagle dogs by iv Xueling(0.02g/kg,0.04g/kg,0.1g/kg).There is not only no drug tolerance after being repeatedly taken Xueling,but also has no influence on heart rate.Conclusion:Xueling has the obvious effect on reducing blood pressure with certain dosageˉeffect relation.
【Fund】: 国家中医药管理局资助项目(No.97L007) ;; 浙江省自然基金资助项目(No.397433)
【CateGory Index】: R285.5
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