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《Journal of Zhejiang College of Tcm》 2003-01
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Influences of Electroacupuncture on Pain Threshold and Antiˉcollagen Antibody,ILˉ1βin CIA Rats

Fang Jianqiao,Kan Fangju Zhejiang College of TCM,Hangzhou(310053)  
Objective:The influences of electroacupuncture(EA)on the pain threshold,NK/LAK cell activities in tumorˉborne rats and painshold,βˉendophine,antiˉC II antibody and interleukinˉ1β(ILˉ1β)levels in CIA rats were observed to investigate the double effects of EA on analgesia and immune regulation as well as their correlations.Methods:Male Wistar rats injected intradermally by bovine type II collagen were induced to collagen arthritis.EA treatment started3days after immunization and applied at Zusanli(ST36)was given for19days We used TFTto measure the pain threshold,Wood's method to evaluate the arthritic index,ELISA to measure the serum antiˉC II antibody and splenic ILˉ1βlevels,and RIA the brain and splenicβˉendophine levels.Results:EA obviously raised the pain threshold of CIA rats,and achieved the immediate analgesic effect in the treatment of different periods.Theβˉendophine levels in brain tissue and spleen of collagen immunized rats were accordingly liftˉed.EA stimulation not only significantly reduced the affected limbs of arthritis,but also lowered the arthritic index and serum antiˉC II antibody level.The concentration of splenic ILˉ1βinduced by collagen injection was notably inhibited.Conclusion:EA possessed strong analgesic effect on experimental rheumatoid arthritis,and activated the release of endogenous opiates.Moreover,EA controlled the disease condition of arthritic rats,remarkably reduced antiˉcollagen antibody and inflammatory cytokine levels.The present study indicates that in the treatment of disorders with pain and immune disturbance,EA therapy can get both effects of analgesia and immune regulation.These two effects are related each other in the treatment with EA.
【Fund】: 浙江省中医药管理局重点课题
【CateGory Index】: R245.97
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