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《Journal of Zhejiang College of Tcm》 2003-01
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Pharmadynamics Analysis to Emodin in Rhizoma Polygoin Cuspidati and Total Saponins in the Root of Astragalus Membranaceus Used on Anti Herpus Virus

Wang Zhijie,Huang Tieniu,Liu Yanwen Medical College of Wuhan University,Wuhan(430071)  
Objective:In order to investigate the mutual actions among effecive components of medicinal Chinese herbs when making up preparaˉtions.Methods:We use ACVas positive control of antiherpes and analyze the combinaiton effects between emodin and total saponins on HSVˉ2333strain using Median Effect Principle with plaque reduction assays.Results:In Hepˉ2cell systems,the median effect doses(ED 50 )of ACV of inhiˉbition on the multiplication of HSVˉ2333Strain was10.85μm/ml.When emodin is combined with total saponins at the ratio of2(Dm)/1(Dm),the ED 50 s of direct virucidal activity,the inhibition effects on the infection and multiplication of HSVˉ2333strain are0.73μm/ml,1.04μm/ml and0.83μm/ml respectively.When emodin is combined with total saponins at the ratio of1/Dm)/1(Dm),the corresponding ED 50 s are0.13μm/ml,0.45μm/ml and0.53μm/ml separately.When at the ratio of1(Dm)/1(Dm),the corresponding ED 50 s are0.17μm/ml,1.53μm/ml,0.99μm/ml respectively.The combination indexes of three combination ratios above are1,and these results indicate that the two drugs have obvious antiherpes synergism.Conclusions:The TI of ACV to the inhibition of multuplication of HSVˉ2333strain is100.However,the TIs of2(Dm)emodin/1(Dm)total saponins of direct virucidal activity,the inhibition effects on the infection and multiplication of HSVˉ2are408.2,286.5,359.0respectively.The corresponding TIs of1(Dm)emodin/1(Dm)total saponins are1899.2,548.6,465.8separately.The correspondˉing TIs of1(Dm)emodin/2(Dm)total saponins are714.7,79.4,122.7respectively.Therefore,1(Dm)emodin/1(Dm)total saponins should be the ratio for first choice.
【Fund】: 湖北省自然科学基金资助
【CateGory Index】: R285.5
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