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《Journal of Zhejiang College of Tcm》 2003-03
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Weierkang Granule Treat Chronic Atrophic Gastritis

Chen Zhiyun,Mo Yunsong,Xiang Baikang,et al Hospital Affiliated to Zhejiang College of TCM,Hangzhou(310006)  
Objective:Observe the effects of Weierkang granule on chronic atrophic gastritis patients and model rats.Methods:(1)Clinical research:Choose 31 cases of chronic atrophic gastritis accompanied by intestinal changes and dysplasia definitely diagnosed by gastroscope and pathologic examination,who take Weierkang granule;observe the improvement of clinical symptoms.Remake gastroscopic and pathologic examination within 2 weeks after treatment to 19 cases,and observe the pathologic improvement.(2)Experimental research:Make rats CAG model with alcohol,deoxysodium cholate and ammonia water,then randomly divide them into high dosage and low dosage groups of Weierkang,folic acid group and model group,make another normal group.Observe gastric mucosa inflammation and atrophy after 13 weeks of treatment.Results:(1)Weierkang has good therapy to chronic atrophic gastritis,the total effective rate of patients' clinical symptoms is 78.95%;68.42%to atrophy;78.95%to intestinal gland change;6 cases of dysplasia patients are all reversed.(2)There's no marked meaning to the differentiation of gastric mucosa inflammation among the high dosage and low dosage groups of Weierkang,folic acid group,model group and normal group(P0 05).The rats of model group have severer gastric mucosa than those of normal group,whose differentiation has obvious meaning(P0 01). The rats of the high dosage and low dosage groups of Weierkang and folic acid group have less sever atrophy than those of model group,whose differentiation has very obvious or marked meaning (P0.01,P0.05).Conclusion:The traditional Chinese drug Weierkang has good curative effect to chronic atrophic gastritis patients,it can also improve and reverse the rats'gastric atrophy of experimental atrophic gastritis.
【Fund】: 浙江省科技厅资助项目 :No:943017;; 浙江省中医管理局资助项目 :No:2000C26
【CateGory Index】: R259.7
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