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《Journal of Zhejiang College of Tcm》 2003-06
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Experimental Research of the Effect of Centella Asiatica Compound on Renal Cytokines mRNA Expression in Mice FGS Model

Wang Jun, Chen Xiaoxia,Wang Shenqi, et al The Second Hospital Affiliated to Zhejiang College of TCM, Hangzhou(310007)  
Objective: To research the effect of anti-glomerulosclerosis and cytokine mRNA expression by Centella Asiatica Com-pound(CAC) in mice focal Glomerulosclerosis(FGS) nephritis model. Methods:Mouse FGS model was induced by adromy-cin(ADR),and then treated with CAC for four weeks. The urine protein and pathologic change of the kidney were measured . The total RNA was prepared from the kidney tissue at the end of first week and fourth week, and then the product of reverse transfer was hybridized with the cytokines genes microarray. Results: The result of urine protein in CAC treatment group was hybridized with the cytokines genes microarray. Results: The result of urine protein in CAC treated group was lower than that of model contrast group. Pathologic change of the kidney was improved by CAC. The results of DNA microarry examination indicate:The mRNA expression of PDGF-α, PDGF-β, PDGF-R, VEGF, IL-9, IL-7R2, MIP, c-myc and Jun etc were down-regulated after treated by Centella. At the same time, the expression of Gm-CSF was up-regulated after treated by CAC . Conclusion: CAC has the function of anti-glomerulosclerosis, which probably is obtained through the modulation of various cytokines.
【Fund】: 杭州市科委重大项目资金资助(2000113A09)
【CateGory Index】: R285.5
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