Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Zhejiang College of Tcm》 2004-01
Add to Favorite Get Latest Update

Experimental Study on the Prevention and Treatment Effects of Tiangu Granule on Noise-induced Hearing Loss

Liu Jinhong,Wang Yonghua,Zhao Jinxiao,et al Zhejiang College of TCM,Hangzhou(310053)  
Objective:To observe the prevention and treatment effects of Tiangu granule on noise induced hearing loss in guinea pigs.Methods:The guinea pigs were divided into four groups:normal group,model group,prevention group and treatment group.The latter three groups were exposed to 4 KHz steady white noise at 110 dB SPL for 6 days intermittently(6h/d).Tiangu granule (15ml/kg/d,calculated in accordance with 30g/kg/d of the crude drug) was given to the prevention group and treatment group for 13 days beginning separately from the 7th day before noise exposure and the day after noise exposure,and the same volume of physiological saline was given to model group in the same time with prevention group.ABR(Auditory Brainstem Response)was used to assess the variation of the auditory function in each group of animals.The number of the outer hair cells was counted under the light microscope and the morphological changes of cochlea were observed under the scanning electronic microscope.Results:Compared to model group and treatment group,prevention group showed significantly lower ABR threshold( P 0 05),shorter latency ( P 0 01),more survival of outer hair cells( P 0 01)as well as slighter morphological lesion of cochlear hair cells.Compared to model group,treatment group showed significantly lower ABR threshold( P 0 05),shorter latency( P 0 01),but there was no significant difference between them in the survival of outer hair cells( P 0 05),and the morphological lesion of cochlear hair cells was also similar.Conclusion:Tiangu granule has obvious prevention effect on noise induced hearing loss.It also has certain treatment effect on improving auditory function.The prevention effect is much better than the treatment effect.
【Fund】: 浙江省中医管理局普通课题 (编号 :2 0 0 0C1 9)
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 Wang Yonghua;Lob Lanhua; Zhu Xiangcheng; et al(Zhejiang College of TCM, Hangzhou 310009);Experimental Study on TCD Tiangu's Prevention and Cure to Gentamicin Ototoxity[J];Journal of Zhejiang College of Tcm;1999-04
2 Liu Jin-hong,et al (Zhejiang College of Traditional Chinese Medicine,Hangzhou 310053);CLINICAL AND EXPERIMENTAL STUDIES ON THE INTERVENIENT EFFECT OF TIANGU GRANULE ON DEAFNESS CAUSED BY THE AMINOGLYCOSIDE ANTIBIOTICS[J];Chinese Journal of Traditional Medical Science and Technology;2002-03
Chinese Journal Full-text Database 10 Hits
1 ZHAO Ming,SUN Su-xin(Department of Pediatrics,Fuyang People's Hospital,Anhui 236004,China);Application and study of brainstem auditory evoked polentials in neonatal hyperbilirubinemia[J];Anhui Medical and Pharmaceutical Journal;2007-12
2 TONG Jian-bing,WANG Xiao-yan,GAO Ning-bin(Department of Neurology,the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China);Change of P300 in Hepatolenticular Degeneration Patients with Treatment Combining Traditional Chinese and Western Medicine[J];Journal of Anhui Traditional Chinese Medical College;2007-06
3 WANG Xiu-min,SUN Da-shan(Electromyography Room,Suzhou Municipal Hospital,Anhui 234000,China);Value of diagnosis and treatment visual evoked potential in patients with optic nerve contusion following ocular damage[J];Journal of Bengbu Medical College;2008-01
4 WEI Li-guo~1,LI Xue-en~2,LIANG Miao~1(1.Department of Electronic Engineering, School of Information Science and Technology, Beijing Institute of Technology, Beijing100081, China; 2.Institute of Automation, Chinese Academy of Sciences, Beijing100080, China);Independent Component Analysis and Its Application in the Estimation of Event Related Potentials (ERP)[J];Journal of Beijing Institute of Technology;2004-01
5 Pan Ying-fu et al;Studies of Segmental Somatosensory Evoked Potentials on Patients with Lumbar Disc Herniation and Spinal Canal Stenosts[J];Beijing Medical Journal;1990-04
6 Chen Kui,Pan Yingfu,Tie Yanmei,et al (Department of Neurology, Beijing Friendship Hospital,Beijing 100050);The single-trial of visual evoked potential and the preliminary study on feasibility in clinical practice[J];Beijing Medical Journal;2003-03
7 Xu Jinsen et al ( Fujian Institute of Traditional Chinese Medicine , Fuzhou );The Topographical Feature of Cortical Somatosensory Evoked Potential during Blocking of the Propagated Sensation along Meridians[J];China Journal of Traditional Chinese Medicine and Pharmacy;2002-11
8 张秀清,朱日华,周岱红,李以敏;Adaptive Segmentation and Classified Archiving of EEG Signals[J];JOURNAL OF BINZHOU MEDICAL COLLEGE;1994-02
9 FANG Ming-hui CAO Shu-chen SUN Yan-jun (Affiliated Hospital of Chengde Medical College,Hebei Chengde 067000,China);THE VALUE OF BRAINSTEM AUDITORY EVOKED POTENTIALAND MORPHOLOGICAL CHANGES OF BASAL CISTERN FOR PROGNOSIS OF SEVERE HEAD INJURY PATIENTS[J];Journal of Chengde Medical College;2008-01
10 ZHENG Zhong, HU Xiao-mei, TIAN li, et al Adviser: SONG Kai-yuan (Chengdu University of TCM, Sichuan 610075 Chian);Experimental Study on Electroacupuncture Improving Cervicogenic Sensorineural Hearing Loss and Chronic Inner Ear Ischemia[J];Journal of Chengdu Unversity of Tarditional Chinese Medicine;2005-03
China Proceedings of conference Full-text Database 2 Hits
1 Xu Hong, Li Meishan, Xu Fei, et al. Department of Neurology, First Affiliated Hospital of Kunming Mecical College, Kunming 650032;Examination of event related potential and evaluation to emotional disorder in multiple sclerosis[A];[C];2005
2 TANG Qi-sheng,XIE Li-jun,HUO Ai-rong. (The Dongfang Hospital of Beijing University of TCM,Beijing 100078,China);A comparative study of brain evoked potentials in depression disease patients treated by traditional Chinese medicine[A];[C];2006
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Wang Yonghua;Lob Lanhua; Zhu Xiangcheng; et al(Zhejiang College of TCM, Hangzhou 310009);Experimental Study on TCD Tiangu's Prevention and Cure to Gentamicin Ototoxity[J];Journal of Zhejiang College of Tcm;1999-04
3 Zeng Zhaolin Zhang Meili Zhuang Jianqing (Shanghai College of Traditional Chinese Medicine);PREVENTIVE EFFECT OF THYROID HORMONE ON KANAMYCIN INDUCED DEAFNESS IN GUINEA PIGS[J];Chinese Journal of Applied Physiology;1987-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved