Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Zhejiang College of Tcm》 2005-05
Add to Favorite Get Latest Update

Research on Mechanism of the Blood Sugar Reduction of Lentinan to Rats with High Blood Sugar

Wang Huiming,Xiang Weilan,Pan Hongming,et al Zhejiang College of TCM,Hangzhou(310053)  
Objective:Research the effects of Lentinan(LNT) on the levels of blood sugar,sugar tolerance and serum insulin of experimental rats,aiming for new methods for treating diabetes.Methods:Make animal model of diabetes by abdominal injection of alloxan(120mg/kg) to 30 Wister rats weighing 250±20g,and randomly divide them into 4 groups,respectively administer normal saline,low-dosage(100mg/kg) and high-dosage(200mg/kg)LNT, hydrochloric acid dimethyldiguanide for stomach perfusion,test for 21 days,observe and compare the functions of LNT.Results:LNT can markedly reduce blood sugar(P0.05) with time-effect and dosage relationship, but there’s no obvious differences on blood sugar reduction between high-dosage group and control group statistically(P0.05).During the test period,LNT can much improve sugar tolerance of rats with high blood sugar(P0.05), however has no obvious effect on serum insulin(P0.05).Conclusion:LNT has marked function of blood sugar reduction and improving sugar tolerance,which are not done through insulin.
【Fund】: 浙江省中医药管理局2003年科研项目
【CateGory Index】: R285;
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 YIN Yan-li et al(College of Bioengineering,Henan University of Technology,Zhengzhou,Henan 450001);Study on the Extraction of Lentinus edodes and Ganoderma lucidum Mycelia Polysaccharides and the Compound Anti-oxidative Activity[J];Journal of Anhui Agricultural Sciences;2010-18
2 LIU Cheng-rong(Department of Enviromental and Science,Putian University,Putian Fujian 351100,China);Influence on Submerged Culture of Lentinula Edods in Carbon-nitrogen and Their Ratio[J];Journal of Dezhou University;2007-06
3 FENG Wei,ZHOU Xiao-fen,LIU Zhen-yu,YANG Jun-fang(Institute of Resources and Environment,Hebei Academy of Agriculture and Forestry Sciences,Shijiazhuang 050051,China);Resources of Anti-diabetic Plants in Hebei Province[J];Journal of Hebei Agricultural Sciences;2011-06
4 ZHANG Xing-fang1,WANG Yin-yu2,GONG Guang-yu2,GUO Ben-heng2,WU Zheng-jun2(1.College of Food Science,Shanghai Ocean University,Shanghai 200090,China;2.Technology Center,Bright Dairy and Food Co,Ltd,Shanghai 200072,China);The Effect of Cyclodextrin Glucanotransferase on the Glucose Tolerance and Glycogen Change of Diabetic Rats[J];Acta Agriculturae Boreali-Sinica;2008-S2
5 WU Qingping1,XIAO Chun1,2,3,YANG Xiaobing1,ZHANG Jumei11Guangdong Institute of Microbiology,Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Guangdong Open Laboratory of Applied Microbiology,Guangzhou,Guangdong510070,China;2South China Sea Institute of Oceanology,Guangzhou,Guangdong510301,China;3Graduate University of the Chinese Academy of Science,Beijing 100049,China;Hypoglycemic Effects of Components Extracted from Edible and Medicinal Fungi and Their Mechanisms of Action[J];Acta Edulis Fungi;2009-03
6 ZHANG Zhong,HUANG Li-hua,ZHANG Ling,GUO Xian-xia(College of Chemistry and Life Science,Guangdong University of Petrochemical Technology,Maoming 525000,China);Hypoglycemic Effect of Water-soluble Polysaccharides from Litchi Flesh[J];Food Science;2013-15
7 DU Mei, ZHANG Song(Coll. of Life Sci. S. Chn. Normal Univ. Guangzhou 510631);Mechanism of Edible Fungal Polysaccharide on Reducing Blood Sugar[J];Journal of Microbiology;2007-02
8 Zhang Xin,Zhang Qiang1 and Liang Yanlong(College of Biology and Agricultural Engineering,Jilin University,Changchun 130022;1School of Pharmacy,Changchun University of Chinese Medicine);Development of Research on Antitumor and Hypoglycemic Activity of Lentinan[J];Chinese Pharmaceutical Affairs;2008-02
9 DENG Hang1,2,HE Min1,LI Jiang1,2,LUO Xu-yan1,HUNG Ren-bin1(1.Pharmaceutical School,Guangxi Medical University,Nanning 530021,China;2.Affiliated Hospital of Guilin Medical College,Guilin 541001,China);Hypoglycemic Effect of Persimmon Leaf Polysaccharide in Diabetic Mice Induced by Streptozotocin[J];Chinese Journal of Experimental Traditional Medical Formulae;2011-04
10 Hou Qiongfang,Peng Ruiguang (Drug and Equipment Section,Langzhong Municipal People's Hospital, Langzhong,Sichuan 637400,China);Study on the extraction and the hypoglycemic effect of total flavonoid from mulberry leaves[J];Journal of Modern Medicine & Health;2013-16
【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHAO Liebin, NING Guang, WANG Qinqin et al. Diabetes Center of Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai Institute of Endocrinology, Shanghai 200025;Effects of food rich in soluble fiber on first and second meal tolerance in patients with type 2 diabetes[J];Shanghai Medical Journal;2001-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Qiu Jiongliang, Chang Yan, Zhu Xinqiang Department of Toxicology, Zhejiang University, Hangzhou\ 310006;USE IN VIVO MULTIPLE ENDPOINTS ASSAY FOR STUDYING ESTROGENICITY OF ENDOSULFAN[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1999-05
2 SHAN Bao-en 1 ,GUO Lan-tao 1 ,DONG Qing 1 ,MA Hong 2 (1.Research Center,The Fourth Hospital of Hebei Medical University,Shijiazhuang,050011,Hebei,China; 2.MD Technologies,Inc.845Pheasant Woods Drive Manchester,Mo63021,USA);Syk Can Influence As_2O_3 Induc ed Brain Tumor Cell Cycle Defects[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-06
3 SHAN Bao-en1,LIU Dong-qing2,LIANG Wen-jie1,ZHANG Jing1,LI Qiao-xia1(1.Research Center of the Fourth Hospital of Hebei Medical University,Shijiazhuang,050011,China;2.The First Hospital of Handan);The Anti-tumor Effect and Immunoregulatory Activity of PE2 From Rhizoma Menipermi Extracts in Vivo[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-05
4 SHEN Ye-shou,ZHENG Li-jun,WANG Zheng-liang,GU Li-ping(Laboratory of Glycoconjugate and Glycotechnology, Institute of Biochemistry and Microbiology, Anhui University, Hefei 230039,Anhui, China);Experimental Study on Anti-tumor Effects of Intracellular Polysaccharide from Phellinus Linteus[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-04
5 Li Guoxian;Analgesic and Central Inhibitory Action of the Essential of Aristolochia Mollisima[J];Journal of Anhui University(Natural Sciences);1989-01
6 CHEN Qin~1, TAO Xia-ping~2 (1.School of Life Science, Anhui University, Hefei230039,China; 2. China Academy of Traditional Chinese Medicine, Beijing100700, China);Experimental study of baochunjing capsules on effect of nourishing kidney and tonic yang[J];Journal of Anhui University(Natural Sciences);2004-03
7 DENG Xu et al (The National Base of Life Science and Biotechnology Education,Northwest A & F University,Yangling,Shaanxi 712100);Preliminary Study on Antimicrobial Activity of Fermentation Broths of Oudemansiella mucida[J];Journal of Anhui Agricultural Sciences;2006-19
8 ZHANG Gui-zhi et al(Animal Science Department,Zhengzhou College of Animal Husbandry & Engineering,Zhengzhou,Henan 450011);Joint Antibacterial Action between TMP and SMM in Vitro[J];Journal of Anhui Agricultural Sciences;2007-36
9 CAI Zhi-hua(Institute of Bio-pharmacies,College of Life Science,Chongqing Normal University,Chongqing 400047);Primary Exploration on the Extraction Technology of Crude Superoxide Dismutase from Chinese Quince[J];Journal of Anhui Agricultural Sciences;2008-05
10 CHEN Jiong-ran et al(Lanzhou Institute of Animal Husbandry and Veterinary,Chinese Academy of Agricultural Sciences,Lanzhou,Gansu 730050);Research on the Effect of the Compound Oral Chinese Medicine on Anti-inflammatory of Mice[J];Journal of Anhui Agricultural Sciences;2010-26
China Proceedings of conference Full-text Database 10 Hits
1 HU Xiao-bo,LIU Yang,ZHANG Xue-nong 1 (Department of Pharmaceutics,School of Pharmaceutical Science,Suzhou University;Jiangsu Suzhou 215123);Study on the anti-tumor activities of pH-sensitive Osthol-Nanoparticles[A];[C];2011
2 WANG Guo-dong WANG Zhu HAN Jun-hua HE Mei Institute of Nutrition and Food Safety,Chinese Center for Disease Control and Prevention,Beijing 100050,China;STUDY OF THE MODULATING EFFECTS OF PHYTOSTEROL ON SERUM LIPID[A];[C];2007
3 ;Study on the Functional Effect of Chufa Functional Component[A];[C];2004
4 Pan Hua-Xin, Wang Pei-Xxun, Zhou Lian, Cao Liu-Ying, Liang Rui-Yan (Immunological Laboratory of Clinical Pharmacology Institute, Guangzhou University of TCM. Guangzhou 510405. China);Comparison of anti-inflammatory and immunosuppress effects of two kind of tablets of tripterygium wilfordii polyglycosidium[A];[C];2006
5 WANG Xiao HU Shixing LIN Shaochun GUO Xuejun ZOU Yihai (Zhongshan Ophthalmic Center, Zhongshan University, Guangzhou, 510060; The Ophthalmology hospital, China Academy of TCM, Bejing, 100040 3 LAC, Guangzhou University of TCM, Guangzhou, 510405);Effects of the Lighting Decoction in models of Acute Light Damage in Rat's Retina[A];[C];2006
6 Zhang Dawei Bing Guoqiang LiPing Yang Donghua Yu Yanbo Liu Zhanjun Guo Chao Xu Caiyun (Center of Laboratory Animal, School of Basic Medical Sciences, Jilin University, Changchun, Jilin, 130021; Laboratory Center, College of Physical Education, Jilin University, Changchun, Jilin, 130012; Observation Room of Laboratory Animal, No. 2 School of Clinical Medicine, Jilin University; Laboratory Animal Room, Changchun Biological Products Research Institute; Changchun Jingyou Medicine Joint-stock Limited Company);Experimental animal barrier environment commonly used disinfection drugs stimulant quality and toxic experiment (五) --Inspiration toxicity experiment of 2% content peracetic Acid solution[A];[C];2006
7 HONG Hua~1,ZHAO Xiang-ren~2,LIU Huai-yu~1 (1.Laboratory Animal Center of Jilin University,Changchun,Jilin,130021 2.Dentrial Medical Colege of Jilin University,Changchun,Jilin,130041 );Safety Reevaluation of Tiopronin Injection[A];[C];2010
8 Suofei -ya Huang peiyou li qiang Wu liya. yiming ( College of Life science and techonolgy, Xinjing University, Wurumuqi, xinjing830046 College of Pharmacy, Xinjiang Medical University, Wurumuqi, Xinjiang 830011);The actue virulence of Cumin Seed Oil and protective effects on the experimental gastric ulcer[A];[C];2005
9 Chen Yan,Wu Li-ya,Chen Rong(Traditional Chinese physician hospital of Xinjiang autonomous region,Urumqi 830054,china);Experimental Study on Protective Effect of Celery root Against Acute Liver Injury[A];[C];2008
10 Yan Zen-kai1, Zhu Hui-ling2, Hu Chun-ju3, Huang Xian-ju2 (1. Department of Chemistry, Hanshan Normal University, Chaozhou 521041; 2. Medical School of Yangtze University, Jingzhou 434000; 3. Department of medical, Hanshan Normal University, Chaozhou 521041);Isolation and Pharmacological Action of Dihydromyricetin[A];[C];2006
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Wang jing Chenqi (Contre of Modern Experiment and Technology Anhui University Hefei 230039)Zhao zhiping Wu dongru (Biology Department AnHui University Hefei 230039);Isolation, Purification and Analysis of the Polysaccharide of Anemarrhan asphodeloides Bge[J];Journal of Anhui University(Natural Sciences);1996-01
2 KONG Xiao-wei~(1,2),LIU Ting-yi,GUAN Jian (1.School of Life Science,Anhui University,Hefei 230039,China; 2.Anhui Key Laboratory of Eco-engineering and Bio-technique,Hefei 230039,China);Effect of polysaccharide from the Gastrodia elata Blume on metabolism of free radicals in subacute aging model mice[J];Journal of Anhui University(Natural Sciences);2005-02
3 WU Jia-di et al (Biological Technology College of Shenyang Agriculture University,Shenyang,Liaoning 110161);Studies on the Enzyme Hydrolysis of Soluble Polysaccharide from Momordica Charantia[J];Journal of Anhui Agricultural Sciences;2005-01
4 ZOU Sheng-qin et al (Institute of Biology, Yichun University, Yichun, Jiangxi 336000);Research Progress of the Nutrient Composition, Pharmacological Effect and Development of Edible Mushroom[J];Journal of Anhui Agricultural Sciences;2005-03
5 ZHANG Xiao-rui et al (Department of Food Engineering,Shaanxi Normal University,Xian,Shaanxi 710062);Effect of Inorganic Salts and Growth Factors on Growth of Agaricus bisporus Strain[J];Journal of Anhui Agricultural Sciences;2007-25
6 GE Shu-min et al(Department of Biotechnology,School of Life Science and Technology of Changchun University of Science and Technology,Changchun,Jilin 130022);Study on the Extraction of Polysaccharide from Agaricus rubellus and Its Anti-tumor Activity in vitro[J];Journal of Anhui Agricultural Sciences;2008-36
7 SHAN Bin et al (Department of Food Science and Technology,Yingdong Biological Sciences School,Shaoguan College,Shaoguan,Guangdong 512005);Study on the Antioxidant Activity of Polysaccharide from Momordica Charantia L.[J];Journal of Anhui Agricultural Sciences;2009-01
8 GE Shu-min et al (College of Life and Scientific Technology,Changchun University of Science and Technology,Changchun,Jilin 130022);Component Analysis and Preliminary Structure Identification on Mongolia Tricholoma Polysaccharide(MOP)[J];Journal of Anhui Agricultural Sciences;2009-01
9 XIA Ping et al (Faulty of Life Science,Huzhou Normal College,Huzhou,Zhejiang 313000);Optimization Techniques for the Extraction of Polysaccharides from Mulberry Leaves by Complex Phosphoesterasum[J];Journal of Anhui Agricultural Sciences;2009-01
10 LIU Jin-hai et al(College of Animal Husbandry and Veterinary,Jilin University,Changchun,Jilin 130062);Effect of Red Wine Lentinan on the Growth Performance and Disease Resistance of Broilers[J];Journal of Anhui Agricultural Sciences;2009-14
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 JIANG Pei-pei et al (Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education,Hainan Normal University,Haikou, Hainan 571158);Extraction of Antioxidant Active Components of Crotalaria mucronata Desv. and Optimization of Activity Determination System[J];Journal of Anhui Agricultural Sciences;2010-28
2 GAO Ming-yan et al(Sichuan Academy of Traditional Chinese Medicine Laboratory of Cellular and Molecular Biology,Chengdu,Sichuan 610041);The Nutritional Composition and Medicinal Physiological Activities of Pleurotus[J];Journal of Anhui Agricultural Sciences;2010-29
3 SHE Yong-hong et al (College of Agriculture, Ningxia University, Yinchuan, Ningxia 750021);Study on the Substrate Inhibition and the Disarming Inhibition Method in the Fermentation Process of Hyaluronic Acid[J];Journal of Anhui Agricultural Sciences;2011-17
4 SONG Wen-hua et al (Freshwater Fisheries Science Institute of Liaoning Privince,Liaoyang,Liaoning 111000);Effect of Astragalus Polysaccharide and Lentinan on the Non-specific Immunity Function of Ctenopharyngodon idellus[J];Journal of Anhui Agricultural Sciences;2011-24
5 LIN Yuan-zhen et al(College of Forestry,South China Agricultural University,Guangzhou,Guangdong 510642);Genome-wide Analysis of Glucose-6-phosphate Dehydrogenase(G6PDH) and Its Evolution in Eucalyptus grandsis[J];Journal of Anhui Agricultural Sciences;2011-29
6 LAI Yong et al(School of Pharmaceutics and Chemistry,Dali College,Dali,Yunnan 671000);Experiment of Periplaneta americana Extracts on Diabetic Mice Induced by Alloxan[J];Journal of Anhui Agricultural Sciences;2012-06
7 TIAN Hong-lei et al(School of Food Science,Shihezi University,Shihezi,Xinjiang 832000);Study on the Intervention of Lactobacillus TZ-5 on Blood Lipid Level of Rats with High-fat Diet[J];Journal of Anhui Agricultural Sciences;2012-12
8 Fan Rui-xin (Xingzhou hospital in Luanping county of Hebei province,Luanping 068250,China);The Study of the Inhibition Effect of Lentinan on Proliferation of Ovarian Carcinoma SKOV3 Cell Line and Growth of Xenograft in Nude Mice[J];Chinese Journal of Medicinal Guide;2010-03
9 ZHANG Shiyuan1 XU Chunyan1 DONG Xiaofang2 TONG Jianming2 ZHANG Qi2 (1. Institute of Animal Science and Technology,Yangzhou University,Yangzhou 225009,China; 2. State Key Laboratory of Animal Nutrition,Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China);Effects of Water Soluble Alfalfa and Astragalus Polysaccharide on Proliferation of Lymphocyte in Broilers[J];Chinese Journal of Animal Nutrition;2010-03
10 PENG Chuan-Cong1,KONG Jing2,YOU Li-Jun2,MA Fang-Li1(1.Infinitus(China) Company Ltd,Guangzhou 510665,China)(2.College of Light Industry and Food Sciences,South China University of Technology,Guangzhou 510640,China);Optimization of Ultrasonic-assisted Extraction Technology of Lentinan Polysaccharides by Response Surface Methodology and its Antioxidant Activity[J];Modern Food Science and Technology;2011-04
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 JIANG XIANCHENG, ZHUANG QINQI, MEI MEIZHEN(Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Shanghai First Medical College, Shanghai);A SIMPLE METHOD FOR THE DETERMINATION OF LECITHIN CHOLESTEROL ACYLTRANSFERASE[J];;1985-02
2 Kong Qingsheng, Wang Yanying, Jiang Ying Department of Biochemistry, Jining Medical College (Jining 272013);Studies on Extraction and Hypolipidemic Activity of Polysaccharides from Pumpkin[J];CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS;2000-03
3 XIE Ming-Zhi, LIU Hai-Fan, ZHANG Ling-Yun, SHEN Zhu-Fang and CHEN Qi-Ming(Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing);AN EXPERIMENTAL RAT MODEL OF OBESITY AND DIABETES[J];Acta Pharmaceutica Sinica;1985-11
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved