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《Journal of Zhejiang College of Tcm》 2005-05
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Research on Mechanism of the Blood Sugar Reduction of Lentinan to Rats with High Blood Sugar

Wang Huiming,Xiang Weilan,Pan Hongming,et al Zhejiang College of TCM,Hangzhou(310053)  
Objective:Research the effects of Lentinan(LNT) on the levels of blood sugar,sugar tolerance and serum insulin of experimental rats,aiming for new methods for treating diabetes.Methods:Make animal model of diabetes by abdominal injection of alloxan(120mg/kg) to 30 Wister rats weighing 250±20g,and randomly divide them into 4 groups,respectively administer normal saline,low-dosage(100mg/kg) and high-dosage(200mg/kg)LNT, hydrochloric acid dimethyldiguanide for stomach perfusion,test for 21 days,observe and compare the functions of LNT.Results:LNT can markedly reduce blood sugar(P0.05) with time-effect and dosage relationship, but there’s no obvious differences on blood sugar reduction between high-dosage group and control group statistically(P0.05).During the test period,LNT can much improve sugar tolerance of rats with high blood sugar(P0.05), however has no obvious effect on serum insulin(P0.05).Conclusion:LNT has marked function of blood sugar reduction and improving sugar tolerance,which are not done through insulin.
【Fund】: 浙江省中医药管理局2003年科研项目
【CateGory Index】: R285;
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