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《Journal of Zhejiang University of Traditional Chinese Medicine》 2008-05
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Effect of Electroacupuncture at Points Zusanli (ST 36) and Sanyinjiao (SP 6) on Collagen-induced Arthritis in Rats and Its Mechanism visa Blood Rheology

Fang Jianqiao,Ma Guizhi,Liang Yi The Third Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou(310009)  
[Objective] To observe the therapeutic effect of electroacupuncture(EA) collagen-induced arthritis(CIA) in rats and explore the partial mechanism via regulating blood rheology.[Methods] Bovine type II collagen was intradermally injected into the back of anesthetized rats to induce arthritis,the animal model of rheumatoid arthritis.Electroacupuncture(continuous waves,2 Hz,5 mA) was applied unilaterally and alternatively to Zusanli(ST 36) and Sanyinjiao(SP 6) for 30min,given once a day for 30 days.The paw edema,pain threshold and joint pathological changes in CIA rats were observed.Some indexes in blood rheology such as viscosity and erythrocyte aggregation were also examined.[Results] EA at point Zuansanli(ST 36) and Sanyinjiao(SP 6) reduced paw swelling and increased pain threshold significantly.Pathological damages of joint in CIA rats were effectively prevented by EA treatment.Meanwhile,the low blood viscosity in EA group were lower obviously than that in control group,and the erythrocyte aggregation indexes were down-regulated by EA.[Conclusion] EA has a pronounced therapeutic effect on collagen-induced arthritis in rats.Regulating the blood rheology in CIA rats may be the mechanism of EA.
【Fund】: 国家自然科学基金资助项目(No.30371802);; 国家重点基础研究发展计划(2005CB523306)~~
【CateGory Index】: R245
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