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《Journal of Zhejiang Chinese Medical University》 2013-08
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Review on Osteoporosis Drugs Targeted Therapy

Ying Jianwei, Li Guijin, Zhu Yincheng, et al Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou(310053)  
[Objective] Summarize the last 10 years of research progress of osteoporosis drugs for targeted therapy.[Method] By searching at home and abroad into bone cells Wnt/beta-catenin signal pathway knowledge and researching literature on osteoporosis drugs targeted treatment of different mecha nisms to summary.[Results] It found DKK1,GSK-3β,bone sclerosis over-expression inhibiting osteoblast activity and function,and treatment of osteo porosis drugs inhibiting the expression of factor pathway and had a positive meaning.[Conclusion] Osteoporosis drugs targeted therapy has good prospects.
【Fund】: 国家自然科学基金项目(81273771);; 浙江省科技厅创新团队项目(2011R50022-09)~~
【CateGory Index】: R580
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 XU Bing1,LIU Hui1,XU Ying-Xing1,WU Yan1,XIAO Lu-Wei1,TONG Pei-Jian2*(1The First College of Clinic Medicine,Zhejiang Traditional Chinese Medical University,Hangzhou 310053,China; 2 Orthopedics,Chinese Medicine Hospital of Zhejiang Province,Hangzhou 310012,China);Development of the classic Wnt/β-catenin pathway in osteoblasts[J];Chinese Bulletin of Life Sciences;2011-05
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 FU Bin1,TANG Guo-hua2. (1. Key Laboratory of Shanghai Stomatology; 2. Dept. of Orthodontics,The Ninth People's Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200011,China);Wnt/β-catenin signaling pathway and bone remodeling[J];International Journal of Stomatology;2010-05
2 XU Ji,ZHOU Jie,TANG Guo-hua.Department of Orthodontics,The Ninth People's Hospital,School of Medicine,Shanghai Key Laboratory of Stomatology,Shanghai Jiaotong University,Shanghai 200011;Effect of Lithium on the Osteogenesis during Mid Palatal Suture Expansion of Rats[J];Journal of Oral Science Research;2010-05
3 Li Sheng-cun,Bao Jie,Wang Guo-xiang Sport and Physical Education School of Soochow University,Suzhou 215000,Jiangsu Province,China;Role of Wnt/beta-catenin signal pathway in the occurrence of osteoarthritis[J];Chinese Journal of Tissue Engineering Research;2012-13
4 FU Bin,ZENG Yun-ting,TANG Guo-hua.(Department of Orthodontics,Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Stomatology.Shanghai 200011,China);Effects of lithium on the healing of tooth extraction sockets in rats[J];China Journal of Oral and Maxillofacial Surgery;2012-01
5 QIN Meng1 CHEN Yuanchuan2 GUOHailing2 DUAN Tieli2 DING Daofang2 ZHAO Yongfang2 SHEN Xueyong1 ZHAN Hongsheng2 1Shanghai University of TCM 2Shi's Center of Orthopedics and Traumatology,Shuguang Hospital Affiliated to Shanghai University of TCM 3Institute of Traumatology & Orthopedics,Shanghai Academy of TCM;Effects of Tonifying Kidney-yang Chinese Medicine on Expression of the Related Proteins of Wnt/beta-catenin Signal Pathway in Osteoblast[J];Chinese Journal of Traditional Medical Traumatology & Orthopedics;2013-05
6 ZHANG Chun-fang;WU Shan;PENG Jin-yong;XIA Fan;WANG Chang-yuan;LIU Qi;MENG Qiang;LIU Ke-xin;SUN Hui-jun;Dept of Clinical Pharmacology,College of Pharmacy,Dalian Medical University;;Dioscin stimulates proliferation and differentiation of MC3T3-E1 osteoblasts via upregulation of Lrp5 and β-catenin expression[J];Chinese Pharmacological Bulletin;2013-09
7 ZHAO Chuang;ZHOU Hao;ZHU Xiao-wen;YE Bin;LI Yun-feng;HU Jing;State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University;Department of Oral and Maxillofacial Surgery,Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital;;Expression of Wnt/β-catenin signal pathway in the stretched rat bone marrow mesenchymal stem cells[J];China Journal of Oral and Maxillofacial Surgery;2013-05
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 LIU Shang-quan,CHEN Ming-dao.Ruijin Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai Institute of Endocrine and Metabolic Disease,Shanghai 200025,China;Progress in glucocorticoid-induced osteoporosis[J];International Journal of Endocrinology and Metabolism;2006-02
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