Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Zoology》 2004-03
Add to Favorite Get Latest Update

Prostaglandin D_2 and Its Receptor in Mammalian Reproductive System

HU Shi Jun ZHU Hui YANG Zeng Ming (College of Life Science, Northeast Agricultural University, Harbin 150030, China)  
Prostaglandin D 2 (PGD 2),a member of prostaglandins (PGs) family,is widely distributed in many kinds of mammalian tissues and exerts important physiological functions. PGD 2 induces sleep, allergic responses, inhibition of platelet aggregation and relaxation of smooth muscle. There are two prostaglandin D 2 synthases which are entirely different in biochemical and immunological functions, including lipocalin (brain) type PGDS (L PGDS) and hematopoietic PGDS (hPGDS). In reproductive system, L PGDS is mainly present in male reproductive tract and involves in testis development, spermatogenesis, sperm maturation, blood testis barrier and blood epididymis barrier. hPGDS is expressed in both pregnant endometrium and trophoblast. Pregnancy may be maintained through its dual receptors, DP and CRTH2. Additionally, PGD 2 may be also related to female infertility and sperm transport through the female genital tract.
【Fund】: 国家自然科学基金资助项目 (No .30 2 70 1 6 3)
【CateGory Index】: Q58
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved