Study on Bezoar (Ox Gallstone) by Fourier TransformInfrared Spectroscopy
Wu Jinguang Shen Guorong Guo Hai Una Huizhen Xu NingZhu Bo Xu Guangxian(Department of Chemistry, Peking University)Zhang Nengrong Wu Shusheng (Beijing Tongrentang Traditional Chinese Medicine Extration Factory)
Bezoar is the gallstone of ox. It is an important ingredient of some Chinese traditional medicines, which have been used to treat coma, delirium, convulsions and so on, but it's effective components and the mechanism of the pharmacology are still not clear.Four specimens of natural bezoar produced from different places (the North China, the South China, India and Argentina) and a smaple of artificial bezoar were studied by FT-IR spectroscopy. The results demonstrated that there is a great difference between the natural bezoar and artificial bezoar.From the subtraction spectra of the bezoar samples using calcium bilirubin as the reference the main bands of proteins were obtained. The secondary structure of the protein in ox gallstone was discussed.Since we have found that the human gallstones have similar components as the natural bezoar, this will provide a valuable information that the human gallstone may be used instead of the bezoar, which is very scarce.