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Study on the Constituents of the Flavonoids and Other Substances From the Peel of Citrus Sinensis (L.) Osbeck

Zhai Fudong Zhang Shufen Wang Xiaoyi Ma Binglun Dai Qianhuan ( Department of Chemistry and Environmental Engineering,Beijing PolytechnicUniversity, 100022)  
Five compounds in the crystal form were isolated from dry peel of citrus Sinensis(L.)Osbeck collected from GuangXi province. By means of physico-chemical evidence andspectroscopic analysis( UV, IR, MS, 1HNMR), three components were characterized as poly-methoxyflavonoids. They were 3, 5, 6, 7, 8, 3', 4'-heptamethoxy flavone (I), tangeretin (II) andnobiletin (III).B-sitosterol (IV) and friedelin( V ), which were also identified. Among them, 3, 5, 6, 7,8, 3', 4'-heptamethoxy flavone and friedelin were first obtained from domestic citrus peels. Heptamethoxy flavone was found having significant inhibitory action in the experiment with human Leukemic cell ( K 562).
【CateGory Index】: O629
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