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《Journal of Beijing University of Chemical Technology(Natural Science Edition)》 2010-03
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In situ preparation and characterizations of drug-loaded magnetic hollow silica microspheres by a pickering emulsion based route

WANG ZhiYan WU Wei ZHANG Kui CHEN JianFeng ZHANG PengYuan(College of Chemical Engineering,Beijing University of Chemical Technology,Beijing 100029,China)  
Nano-Fe3O4 particles have been prepared by chemical co-precipitation.Drug-loaded magnetic hollow silica microspheres(MHSM) were synthesized by an in-situ Pickering emulsion template method,where Ibuprofen and nano-Fe3O4 particles were absorbed in the hollow silica microspheres.The composition,structure and drug release property for as-synthesized material were characterized.The drug-loaded MHSM have an average size of 2 μm and shell thickness of 240 nm with a smooth outer surface and contain Ibuprofen.The shell thickness is increased by the in-situ loading drug,and the MHSM is effective as a drug carrier having a slow-release effect.
【Fund】: 国家自然科学基金(20671010)
【CateGory Index】: TQ460.1
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