Experimental study of adriamycin nanometer particles target therapy on rabbit tongue squamous cell carcinoma

JIN Wu-long,ZHOU Liang,GUO Hui-ling,TIAN Jie. Department of Otorhinolaryngology Head Neck Surgery,Eye Ear Nose and Throat Hospital,Fudan University,Shanghai 200031,China  

Objective To examine the distribution of adriamycin nanometer particles in target organ(tongue cancer)and easy-damaged organs by super-selective lingual arterial intubation.Methods Forty pure-bred New Zealand rabbits inoculated with tongue squamous cell carcinoma were randomized into adriamycin group and adriamycin nanometer particles group,20 animals each.Adriamycin and adriamycin nanometer particles were administered to these two groups respectively through super-selective lingual arterial intubation.1 h,5 h and 15 h after administration,5 rabbits in each group were sacrificed and 1.0 g tissue of tongue,carcinoma,heart,liver,spleen,kidney and 1ml of plasma were collected,and the drug concentrations were examined by high performance liquid chromatography(HPLC).45 days after drug administration,pathological examination of the samples was performed to evaluate the therapeutic effects.ResultsThe drug concentration in tongue carcinoma of adriamycin nanometer particles group was significantly higher than that of free adriamycin group(P0.01),whereas much lower in non-target organs(heart,liver,spleen,kidney and plasma)(P0.01).1 h,5 h and 15 h after administration,the drug concentration was highest in tongue and carcinoma tissue and lowest in heart in nanometer particles group.Pathology showed that only little cancer cells were found.The therapeutic effect of nanometer group attained CR.Conclusion The super-selective lingual arterial administration of adriamycin nanometer particles can markedly enhance drug concentration in the cancer lesion and has better treatment effect.

【Fund】： 中国博士后科学基金资助(20070410691)
【CateGory Index】： R739.86

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