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Studies on the Antibiotic Activity and Its Stability of Chitosan

YE Lei, He Li qian,GAO Tian zhou,LI Li yun (Normal College of Beijing Union University, Beijing 100011, China)  
The antibiotic activity of three kinds of chitosans with different molecular weight(50, 100, 200 kD) and same deacelylated degree(85%), was evaluated against some bacteria(Staphyloccus aurueus, Pseudomonas aeruginosa, Bacillus subtilis, Corynebacterium minutissimum, Escherichia coli, Candida albillus).The growth of all the bacteria tested were inhibited by chitosans treatments, and the inhibiting rate decreased with the rising of chitosan's molecular weight. The minimum inhibitory concentration of all the chitosans is above 0.5 g/L. The effects of temperature, metal ions on the antibiotic activity of chitosans were also assessed.
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