Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Beijing Union University(Natural Sciences)》 2009-01
Add to Favorite Get Latest Update

The Improvement of H_2O_2 Induced Osteoblast Damage by Lycopene

HUI Bo-di~1,PEI Ling-peng~2(1.College of Applied Art & Science of Beijing Union University,Beijing 100083,China;2.Center University of Nationalities,Institute of Chinese Minority Traditional Medicine,Beijing 100081,China)  
Objective:To investigate the effect of lycopene on enhancing the function of anti-oxidative damage in osteoblast.Methods:MC3T3-E1 osteoblasts were randomly divided into five groups,including control group,model group,lycopene group[low dose(1×10~(-8) mol/L),middle dose(1×10~(-7) mol/L),high dose(1×10~(-6) mol/L)],whose activity of cells,superoxide dismutase(SOD),the content of reactive oxygen species(ROS),lipid oxygen(LPO) and membrane fluidity were tested and compared.Results: Compared with lycopene groups,the activity of cells,SOD activity and membrane fluidity in the model group were significantly decreased(P0.01).However,the content of ROS and LPO were significantly raised(P0.01).Conclusion: H_2O_2 can cause oxidative damage of MC3T3-E1 osteoblasts,but lycopene can prevent and decrease its influence.
【Fund】: 北京市自然科学基金对外合作项目资助(SZ20051141720)
【CateGory Index】: Q946;Q2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved