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《LABELED IMMUNOASSAYS AND CLINICAL MEDICINE》 1999-04
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Effect of Chinese Kidney-tonifing Herbal Medicine on Function of M Receptor in Brain Tissue of Aged Rats

Gong Bin, Yang Wengang, Zhang Qian et al. (Shanghai University of Traditional Chinese Medicine, Shanghai 200032)  
We have studied the effect of Chinese kidney-tonifing and Chinese blood-circulation-invigorating herbal medicine on the total receptor concentration (Rt) of cholinergic M receptor and the activity of acetylcholine esterase (AchE) in brain tissue of aged rats using receptor radioligand binding assay (RRLBA) and biochemical enzyme-substrate reaction.The results showed that the Rt value of M receptor was markedly lower and the activity of AchE was markedly higher in brain tissue of aged rats compared with youthful rats. Chinese kidney-tonifing and Chinese blood-circulation-invigorating herbal medicine can markedly inhibit activity of AchE and increase Rt value of M receptor in brain tissue of aged rats. This suggested that Chinese kidney-tonifing and Chinese blood-circulation-invigorating herbal medicine can probably delay aging of brain tissue via inhibiting the activity of AchE and increasing the Rt value of M receptor in brain tissue of aged rats.
【CateGory Index】: R285.5
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