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Effect of Estrogen Replacement Therapy on the Serum Nitric Oxide,NO Synthase and Endothelin-1 Levels of Ovariectomized Rat

ZHANG Ying, ZHANG Bo, WANG Bai-xin, et al. (The Second Affiliated Hospital of Jiamusi University, Jiamusi 154002, China)  
The effect of estrogen replacement therapy on the serum nitric oxide(NO),NO synthase(NOS) and endothelin-1 (ET-1) level of ovariectomized rat was studied. Twenty-one female rats were randomly divided into three group: group A: rats were sham-ovariectomized, group B: rats were ovariectomized and group C: rats were ovariectomized together with estrogen replacement therapy. The rats were killed after one month.The levels of serum NO, NOS and ET-1 in the three groups were determined. In group B, the serum NO, NOS levels were lower and ET-1 level was higher than those in group A( P 0.05).In group C, the serum NO, NOS levels were higher and the ET-1 level was lower than those in group B( P 0.05).Conclusion were estrogen may modulate the production of NO,NOS and ET-1, which might be the possible mechanism of the beneficial effect of estrogen in prevention of atherosclerosis.
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