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《Labeled Immunoassays and Clinical Medicine》 2006-02
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The Changes and Significance of Serum Leptin Levels in Patients Post-liver Transplantation

YAN Guang-tao, XUE Hui, LIN Ji, et al.(Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, Beijing 100853, China)  
To explore the effect of liver transplantation-induced liver ischemia/reperfusion injury on serum leptin levels in these patients, serum samples of patients with malignant primary liver cancer or cholangiocarcinoma who had been given holo-hepatectomy were collected, and RIA and ELISA were used to detect serum levels of leptin, CRP and Interleukin-1β (IL-1β) in these patients. Results showed that compared with self-control before operation, leptin level decreased immediately after operation, continued to decrease after one hour of non-liver period, reached the lowest level after one hour of neo-liver period, and increased to a higher level than that of self-control before operation at ten hours after operation (P0.05). Serum level of CRP had a similar change as that of leptin, reaching the lowest after one hour of neo-liver period and recovering to normal level gradually after that. Serum level of IL-1β also expressed a trend to decrease at the beginning and to recover to normal level at 10 hours after operation. Results showed that serum leptin level decreased significantly in the early!stage of post-liver transplantation and increased thereafter with a significant difference vs that before operation, which occurred concurrently with the changes of acute phase protein CRP and inflammatory cytokine IL-1β, which indicates that leptin plays an important role in liver transplantation.
【Fund】: 国家自然科学基金(No.39970717)
【CateGory Index】: R735
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