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《Labeled Immunoassays and Clinical Medicine》 2006-02
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The Changes and Significance of Serum Leptin Levels in Patients Post-liver Transplantation

YAN Guang-tao, XUE Hui, LIN Ji, et al.(Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, Beijing 100853, China)  
To explore the effect of liver transplantation-induced liver ischemia/reperfusion injury on serum leptin levels in these patients, serum samples of patients with malignant primary liver cancer or cholangiocarcinoma who had been given holo-hepatectomy were collected, and RIA and ELISA were used to detect serum levels of leptin, CRP and Interleukin-1β (IL-1β) in these patients. Results showed that compared with self-control before operation, leptin level decreased immediately after operation, continued to decrease after one hour of non-liver period, reached the lowest level after one hour of neo-liver period, and increased to a higher level than that of self-control before operation at ten hours after operation (P0.05). Serum level of CRP had a similar change as that of leptin, reaching the lowest after one hour of neo-liver period and recovering to normal level gradually after that. Serum level of IL-1β also expressed a trend to decrease at the beginning and to recover to normal level at 10 hours after operation. Results showed that serum leptin level decreased significantly in the early!stage of post-liver transplantation and increased thereafter with a significant difference vs that before operation, which occurred concurrently with the changes of acute phase protein CRP and inflammatory cytokine IL-1β, which indicates that leptin plays an important role in liver transplantation.
【Fund】: 国家自然科学基金(No.39970717)
【CateGory Index】: R735
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 XUE Hui, YAN Guang-tao, ZHANG Kai, et al. (Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, Beijing 100853, China);Developement and Primary Application of an ELISA and Chemiluminescent Immunoassay for C-reactive Protein[J];Labeled Immunoassays and Clinical Medicine;2004-03
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 GE Jun,ZHU Yu-jie,WU Jun,YAO Bei-bei (Faculty of Clinical Medicine,Bengbu Medical College,Bengbu 233030,China);Protective effects of gypenosides on the heart injury after intestinal ischemia-reperfusion in rabbits[J];Journal of Bengbu Medical College;2006-04
2 LUO Gang-jian,GAN Xiao-liang,SHEN Ning,HEI Zi-qing,LI Shang-rong,CHEN Li-xin Department of Anesthesiology,Third Affiliated Hospital,SUN Yat-sen University,Guangzhou 510630,China;Cromolyn sodium ameliorates rat left cardiac function during intestinal ischemia-reperfusion[J];Journal of Southern Medical University;2007-05
3 QI Fei YAN Guang-tao LIN Ji XUE Hui WANG Lu-huan Research Lathoratory of Biochemistry,Basic Medical Institute,General Hospital of PLA,Beijing 100853,China;Serum leptin level increases significantly in acute rheumatoid arthritis[J];Chinese Journal of Rheumatology;2006-06
4 LIUYong-feng,WANG Jin-yue (Foshan Science and Technology College,Foshan528000,China);Research on Leptin Biological Characters and Mechanism of Controlling Weigh[J];Journal of Guangzhou Sport University;2006-03
5 SHEN Bin LIU Liang FU Ru-lian ZHAO Cheng-mei;Discussion on Photodynamic Action of Methylene Blue (MB)[J];Continuing Medical Education;2005-12
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 SHI Yan, YAN Guang-tao, LIN Ji (Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, Beijing 100853, China);Exploration of the Decrease of Leptin Levels induced by Acute Stress Factors[J];Labeled Immunoassays and Clinical Medicine;2004-04
2 Di Kaijun, Liu Shiguang, Zhang Qiuheng,Zhang Jingbo △, (Department of Cell Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Acadamy of Medical Sciences, Beijing);THE STUDY OF BL21(DE3)/PET 28 AS AN EXPRESSION SYSTEM OF HUMAN IL-6[J];ACTA ANATOMICA SINICA;1998-04
3 JI Zhen ling 1,ZHAO Yi bing 1,PENG Shu you 2 (1.Department of General Surgery,Zhongda Hospital,Southeast University,Nanjing 210009,China;?2.Department of Genernal Surgery, the Second Affiliated Hospital,Zhejiang University,Hangzhou 310009,China);The interaction between liver and intestine injury during hepatic ischemia/reperfusion in rats[J];Journal of Nanjing Railway Medical College;2002-02
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