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《Labeled Immunoassays and Clinical Medicine》 2008-04
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The Diagnostic Value of Th1/Th2 Cell Cytokine and Thyroid Autoantibody on Autoimmune Thyroid Diseases

FENG Xue-min,QIN Ming-xiu,ZHAO Yan(Department of Nuclear Medicine,First Central Hospital of Tianjin,Tianjin 300192,China)  
To study the diagnostic value of Th1/Th2 cell cytokine and thyroid autoantibody in autoimmune thyroid diseases(AITD),28 patients with Graves' disease(GD),15 patients with hyperthyroidism and thyroiditis(GDIII),13 patients with Hashimoto's hyperthyroidism(HTL),21 patients with Hashimoto's thyroiditis(HT)and 20 healthy subjects were enrolled in this study.The serum concentrations of Th1 cytokine(IFN-γ) and Th2 cytokine(IL-4) were determined by ELISA.The serum levels of thyrotropin receptor antibodies(TRAb),thyroglobulin antibodies(TGAb) and thyroid peroxidase antibodies(TPOAb) were measured by RIA.The relationship between the serum levels of IFN-γ,IL-4 and TRAb,TGAb and TPOAb were analyzed.The results showed that IFN-γ levels from higher to lower in different groups were in the order of HT,HTL,GDIII,GD and the IL-4 were GD,GDIII,HTL,HT,respectively.There was significant difference in the IFN-γ(P0.05) and IL-4 levels(P0.01)between GDIII and HTL groups.There was no significant difference in TGAb and TPOAb between GDIII and HTL groups.In HT group,IFN-γ levels was positively correlated with TGAb and TPOAb(r=0.67,0.54,P0.01).In GD group,IL-4 was positively correlated with TRAb(r=0.71,P0.01).The imbalance of Th1/Th2 cell cytokine reflects pathologic change and abnormality of immune function in AITD patients.The detection of Th1/Th2 cell cytokine combined with thyroid autoantibody may be regarded as an indicator in the diagnosis of autoimmune thyroid diseases.
【CateGory Index】: R446.62
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