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《Labeled Immunoassays and Clinical Medicine》 2011-02
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Expression of Lymphocyte Subsets and CD25~+ Regulative T Cells in Peripheral Blood of Patients with Chronic Fatigue Syndrome

LIU Ding-hua,LIU Zhan-dong,LI Yong-zhe,ZHANG Hai-ying,HU Chao-jun, ZHANG Yong-bo,WHANG De-xin(Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)  
To investigate the expression of lymphocyte subsets and CD25+ regulative T cells in peripheral blood of patients with chronic fatigue syndrome(CFS).Eighty-four CFS patients and fifty healthy volunteers were enrolled in this study.Their peripheral blood was sampled,and the lymphocyte subsets and CD25+ regulative T cells were measured by flow cytometry.The results showed that the NK cells,CD4+T cells and CD25+ regulative T cells in CFS patients were higher and B cells were lower than that of healthy controls(P0.05),while there was no significant difference between CFS patients and healthy controls with respect to the percentage of T cells and CD8+T cells and CD4+/CD8+ ratio(P0.05).The results indicated that CD25+ regulative T cell might play an important role in CFS-related immunological abnormality,and be involved in the progress of CFS.
【Key Words】: Chronic fatigue syndrome Lymphocyte Regulative T cell Flow cytometry
【Fund】: 国家高技术研究发展技划(863计划)基金资助项目(2006AA02Z436)
【CateGory Index】: R446.6
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 LI Yong-zhe, HU Chao-jun, LIU Ding-hua,TONG Da-wei, ZHANG Shu-lan. Peking Union Medical College Hospital, PUMC & CAMS, Beijing 100730, China;The study of CD4~+ CD8~+、CD4~+ CD25~+ regulative T cells in peripheral blood of patients with primary biliary cirrhosis and its association with the hepatic damnification[J];Chinese Journal of Laboratory Medicine;2005-12
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 YANG Guo-xiang~1,LI Li-jun~2,DONG Xiao-juan~2,et al. (1.China Medical Science Institute Laboratory of PUMMC & CAMS of Bejing Union Hospital Bejing 100032,China; 2.Department of Clinical Laboratory of Iner Mongonia Hospital 010017,China);The analysis of AMA-M2 subtype and karyotype in consecutive patients with postive anti-mitochondria antibodies[J];International Journal of Laboratory Medicine;2010-01
2 WANG Qun-ying, XU Yun. (The First Affiliated Hospital, Zhengzhou 450052, China);SIGNIFICANCE AND CHANGES OF CD4+CD28-T CELLS AND CD4+CD25+ REGULATORY CELLS SUBSETS IN PBMC OF PRIMARY BILIARY CIRRHOSIS PATIENTS[J];Modern Preventive Medicine;2010-06
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Xuan ,LIN Jin,TANG Fulin,et al. Department of Rheumatology,Chinese Academy of Medical Science,Peking Union Medical College,Beijing Union Hospital,Beijing 100730,China;Clinical and pathological features of primary biliary cirrhosis[J];Chinese Journal of Rheumatology;2001-02
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