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《Labeled Immunoassays and Clinical Medicine》 2011-02
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Expression of Lymphocyte Subsets and CD25~+ Regulative T Cells in Peripheral Blood of Patients with Chronic Fatigue Syndrome

LIU Ding-hua,LIU Zhan-dong,LI Yong-zhe,ZHANG Hai-ying,HU Chao-jun, ZHANG Yong-bo,WHANG De-xin(Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)  
To investigate the expression of lymphocyte subsets and CD25+ regulative T cells in peripheral blood of patients with chronic fatigue syndrome(CFS).Eighty-four CFS patients and fifty healthy volunteers were enrolled in this study.Their peripheral blood was sampled,and the lymphocyte subsets and CD25+ regulative T cells were measured by flow cytometry.The results showed that the NK cells,CD4+T cells and CD25+ regulative T cells in CFS patients were higher and B cells were lower than that of healthy controls(P0.05),while there was no significant difference between CFS patients and healthy controls with respect to the percentage of T cells and CD8+T cells and CD4+/CD8+ ratio(P0.05).The results indicated that CD25+ regulative T cell might play an important role in CFS-related immunological abnormality,and be involved in the progress of CFS.
【Fund】: 国家高技术研究发展技划(863计划)基金资助项目(2006AA02Z436)
【CateGory Index】: R446.6
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