The Expression of CD133 and ALDH1 in Ovarian Cancer and Their Correlations with the Prognosis
MA Lin;LIU Xing-qiao;ZHANG Zhi-ge;GAO Min;Department of Gynecology,the Third Hospital of Xingtai of Hebei Province;
Objective To analyze the expression of CD133 and ALDHl in ovarian cancer and their correlations with the prognosis. Methods We collected 132 cases of pathologically diagnosed ovarian cancer from January2015 to January 2017 in our hospital and also collected cases of benign ovarian tumors and normal ovarian tissues in the same period of time with 35 cases for each. The expression of CD133 and ALDH1 in specimens of ovarian cancer were detected by histochemistry. The relationship between the expression of CD133 and ALDH1 in ovarian cancer and clinicopathological features were analyzed. Spearman rank correlation test was used to analyze the correlation between CD133 and ALDH1 in ovarian cancer. Results The positive rates of CD133 and ALDH1 in ovarian cancer tissues were significantly higher than those in normal ovarian tissues(P0. 05). There were no differences in the positive rates of CD133 and ALDH1 between benign ovarian tumors and normal ovarian tissues(P 0. 05). However, the positive rates of CD133 expression between ovarian cancer and benign ovarian tumor was statistically different(P 0. 05), while the positive rates of ALDH1 expression was not(P 0.05). In ovarian cancer, the expression of CD133 was closely related to FIGO stage and lymph node metastasis(P 0.05), while the expression of ALDHl was closely related to the degree of differentiation,lymph node metastasis and preoperative CA125 level(P 0.05). The correlation test showed that the expression of CD133 and ALDHl in ovarian cancer were positively correlated(P 0. 05).Conclusion CD133 and ALDHI are overexpressed in ovarian cancer tissues, which are closely related to the progression of the disease and prognosis. The combined detection of CD133 and ALDH1 is expected to be a molecular marker of ovarian cancer for the prediction of poor prognosis.
【CateGory Index】： R737.31