Effect of Growth Hormone on Rat Renal Cytochrome P450 4A2
Mo Qizhong;Nisar A Pampor;Bernard H Shapiro (Shanghai University of Chinese Traditional Medicine Shanghai 200032)
The effects of growth hormone on rat renal microsome cytochrome P450 4A2 was investigated with immunoblotting. The content of renal microsome cytochrome P450 4A2 of normal male rats was higher than that of normal female rats,indicating that sex-related difference observed in rat hepatic cytochrome was also found in rat renal microsome cytochrome.The levels of renal microsome cytochrome P450 4A2 of both hypophysectomized male and female rats were elevated,being significantly higher than those of the normal rats,while the difference between those of male and female rats was not significant.The content of renal cytochrome P450 4A2 in sodium glutamate-treated male rats was higher than that of normal rats,however the level of MSG treated female rats was markedly lower than that of normal female rats,suggesting that growth hormone has a positive regulatory effect on female rat renal cytochrome P450 4A2,but its effect on the male rat renal cytochrome is somewhat more complex.
【CateGory Index】： R965