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《Journal of Beijing Sport University》 2008-02
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The Protective effects of Exhaustive exercise Metallothionein in Induced by Zinc on Myocardium in Heart of Rats

SONG Chen1,ZHANG Jun2 (1.Physical department of HeFei university of Technology,HeFei 230009,AnHui China;2.College of Physical Education of YangZhou university,YangZhou 225002,JiangSu China)  
Objective :This paper discusses the protective effects of MT on heart, through analysis exhaustive exercise induced by zinc in rat heart.Method:30 Sprague-Dawley rats with weight between 220g to 250g are selected and divided into 3 Groups randomly: Group A is a controlled group without exercise,Group B is the exhaustive swimming exercise group,Group C is the zinc +exhaustive swimming exercise group,with 10 rats in each group.After 8 weeks,the contents of MT,the levels of MDA,the contents-SH,the contents of Ca2+,the activity of GSH-px and Na+-K+-ATP's enzyme in myocardial of rats are measured.Result : 1.Compared with the controlled Group A,the MT contents of rats in Group B are obviously decreased(P0.05),the contents-SH and the activity of GSH-px and Na+-K+-ATP's enzyme are obviously decreased(P0.05),while the levels of MDA and the contents of Ca2+ increased(P0.05).2.Compared with the exhaustive exercise group Group B,the contents of MT of rats in Group C are notably increased(P0.05),the-SH contents and the activity of GSH-px and Na+-K+-ATP's enzyme are obviously increased(P0.05),while the levels of MDA and Ca2+are obviously reduced(P0.05).Cnclusion : By zinc inducing in exhaustive exercise may be reduce the contents of MT obviously descend in rats' myocardial,decrease lipid peroxidationl,increase the activitys of antioxidant enzymes,prevent calcium from overloading,protect cardiomyocytes against injury.MT and metal Zn are mutually related and interacted closely,they probably participate in protecting organism organization from injury and promoting the quickly repairing of the.injury organization after exhaustive exercise.
【CateGory Index】: G804.21
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