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《Journal of Beijing Sport University》 2009-12
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The Effect of Aerobic Exercises to Improve Diabetic Kidney Function of Rats

HE Dai1,HOU Gai-xia2(1.Department of Physical Education,Xi'an Jiaotong University,Xi' an 710049,Shaanxi China;2.Institute of Physical Education,Henan University,Kaifeng 475001,Henan China)  
Objective:To investigate the protective effect of aerobic exercises on renal function and its possible mechanisms on rats with diabetic nephropathy(DN).Methods: Diabetes is induced by intraperitonal injection with streptozotocin(STZ) in male Wistar rats.The fasting blood glucose(FBG),blood urea nitrogen(BUN),serum creatinine(Cr) and urine protein 24h(UP 24 h) are measured on commercially used kits.Meanwhile,superoxide dismutase(SOD) activity,malondialdehyde(MDA) content in serum,aldose reductase(AR) mRNA,TGF-β1 mRNA and SmadProtein expression in kidney are detected by different methods.Results: The treatment of berberine significantly ameliorated the above indices including FBG,body weight,KW /BW,BUN,Cr and UP 24h compared with model group(P0.05). Berberine significantly increases SOD activity and decreases MDA content in serum compared with those in model group(P0.05).mRNA,TGF-β1 mRNA and Smad protein expression in kidney is remarkably decreased in berberine group compared with the model group(P0.05).Conclusions: These results suggested that aerobic exercise can ameliorate renal dysfunction of rats with DN through blood glucose control,reduction of oxidative stress,inhibition of the activation of polyol pathway and inhibition of the activation of TGF-β1/Smad pathway.
【Fund】: 陕西省科学技术研究发展计划项目(项目编号为2009KW-20)
【CateGory Index】: G804.7
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