Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Beijing Medical Journal》 1980-02
Add to Favorite Get Latest Update

IN VIVO EFFECT OF CHINESE MEDICAL COMPOSITUS AND ADENOSINE 3′5′-cAMP ON EHRLICH ASCITES TUMOR CELLS AND ON THE CHANGES OF THE LEVELS OF cAMP AND 3′5′cAMP—PDE ACTIVITY IN THESE TUMOR CELLS

Wang Kun Ren Zhao Ya Li Wang Dai Shu Zhao Meng Lian Lin Rui Yu Meng Song Niang Gao Yan LüZhi Liang Ya Yun Dept. of Cell Biology, Beijing Institute or Cancer Research  
This experiment were carried out in young adult albino mice. which were injected with Ehrlich ascites tumor ceils to produce Ehrlich ascites tumor and divided into 3 groups: first group of these animals was injected intraperitoneolly 0.2 ml. of our preparation of the water extract of a mixture of six kinds of Chinese medical herbs. At the same time, these animals were also given 0.3 c. c. of diluted alcohol extract of whole toads every other day until 8 dayS. Second group of mice received cAMP and aminophylline for same period. Third group of mice received saline as control. We found that this Chinese medical compositus could inhibit the growth of Ehrlich tumor cells in the ascitic fluid as well as the administration of cAMP together with aminophylline. The higher the concentration of cAMP, the lower the rate of the growth of the tumor cells. It also elevated the intraeellular concentration of cAMP, and inhibited the activity of 3'5' cAMP-PDE. These results indicate that the effect of this kind of Chinese medical compositus may serve to modulate the level of CAMP by inhibiting phosphodiesterase, since the effect was showed just as a posent inhibitor of this enzyme,
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 8 Hits
1 CHEN Bing-sheng ZENG Xi-lan LIU Xiu-gin (Department of Nuclear Medicine, Sun Yat-sen University of Medical Sciences)JIAN Zhi-han YANG Hui-ling PAN Wei-xiong (Deqartment of Pathophysiology, Sun Yat-sen University of Medical Sciences);THE EFFECT OF NEO-HUTTUYNINUM ON ERILCH ASCITES CANCER IN MICE AND ON THE LEVELS OF C-AMP IN THESE TUMOR CELLS IN VIVO[J];Chinese Journal of Cancer;1988-01
2 Li Yu-min;Exogenous cUMP on the ~3H-TdR Incoiporation of DNA and the Level of cANP and cGMP in Ehrlich Ascites Tumor Cells[J];;1982-03
3 Yang Shuliang Wang Yang Chen Ning Harbin University of Commerce(Harbin,150076,China);Study on A canthopanax Senticosus Polysaccharide of the Present Situation and the Progress[J];Heilongjiang Medicine Journal;2006-06
4 ;Study Progress in Chemical Composition and Pharmacology of Indian Mockstrawberry Herb[J];Guiding Journal of TCM;2006-11
5 Zhang Jingbo (Department of cell biology. Cancer Institute, ChineseAcademy of Medical Sci.) LiuYu (Department of cell biology, Institute of Bacic Medical Research, Chinese Academy of Medical Sci.);INHIBITION OF CELL GROWTH OF HUMAN HEPATOMA CELL LINE BEL-7402 BY DIBUTYRYL CYCLIC AMP AND AMINOPHILLINE[J];Acta Anatomica Sinica;1981-02
6 ZHANG Zeng-jian(The Fifth Hospital of Xingtai City,Xingtai 054000,Hebei,China);Clinical research about Sihuang Quyin Decoction treating psoriasis vulgaris[J];Liaoning Journal of Traditional Chinese Medicine;2008-07
7 LIN ZHONG-XIANG,WANG DAI-SHU,ZHAO MENG-LIAN,GAO JIE,AND WANG KUN-JEN (Department of Cell Biology,Beijing Institute for Cancer Research,Beijing,China);IMMUNOFLUORESCENT LOCALIZATION OF ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE (cAMP) AND THE EFFECT OF EXTRANEOUS cAMP TO THE INTRACELLULAR cAMP OF EHRLICH ASCITES TUMOR CELLS OF MICE[J];Acta Biologiae Experimentalis Sinica;1982-01
8 FANG JIA-CHUN,FAN BAO-RONG,ZHAO YA-LI,GAO JIE MENG SONG-NIANG,AND WANG KUN-REN (Department of Cell Biology,Beijing Institute for Cancer Research);OBSERVATIONS ON INTRACELLULAR cAMP LEVEL AND cAMP-PDE ACTIVITY IN BW_(5147) CELLS,RETICULOCYTES OF MOUSE AND THE CYBRIDS FUSED BETWEEN THEM[J];Acta Biologiae Experimentalis Sinica;1984-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Cheng Xiu-juan, Li Pei-zhen,Sheng Xiao-hua, Li Bai-jun, Zhu Chun-laiDepartment of Pharmacology, Shenyang College of Pharmacy, Shenyang;ANTITUMOR ACTION AND IMMUNOLOGICAL ACTION OF ACANATHOPANAX SENTICOSUS POLYSACCHARIDES[J];Chinese Journal of Cancer;1984-03
2 ZHAO Ai-guang 1* ,YANG Jin-kun 1 ,ZHAO Hai-lei 1 ,LIU Li-kun 2 1.Department of Oncology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,P.R.China2.Shangxi Chinese Medicine Institu te,Taiyuan 030;Apoptosis Induction by Sijunzi Deco ction in Human Gastric Cancer Xenografts in Nude Mice[J];Chinese Journal of Cancer;2001-02
3 Dept.Cell Biol.,Beijing Institute for Cancer Research. Tumor Section, Pharmacol., Institute of China Materia Medica, Acad. of Trad. Chinese Med., Beijing.;THE EFFECT OF THE EXTRACT OF CHU-LING (POLYPORUS UMBELLATA) ON THE INCORPORATION OF ~3H THYMIDINE AND THE ACTIVITY OF cAMP PHOSPHODIESTERASE OF SARCOMA 180 ASCITES TUMOR CELLS.[J];Beijing Medical Journal;1979-03
4 WU Xian - hua (Central Hospital of Enshi Auto - prefecture, Enshi, 445000, China);Studies on Malignant Tumor Cases under the Treatment of 91 WBD-increasing Drinks with Chemotherapy[J];Journal of Hubei Institute For Nationalities Medical Edition;2002-03
5 XIANG Dong-hua, WU Xian-hua, MIN Gui-fang, et al. ( Department of Oncology , Central Hospital of Enshi Autonomous Prefecture, Enshi, 445000,China);Effect of 91 WBC-increasing Drinks in Efficacy Enhancing and Toxicity Reducing of Radiotherapy in Patients of Malignant Tumor[J];Journal of Hubei Institute For Nationalities Medical Edition;2003-01
6 AI Ming-xian,WU Xian-hua, LI Zuo-pin, et al. (Medical College,Hubei Institute for Nationalities,Enshi 445000,China);Protective Effects of 91WID on Leukocyte of ~(60)Co-ray Irradiated Mice[J];Journal of Hubei Institute For Nationalities Medical Edition;2004-01
7 Wei Chuanwan Zeng Heping Wang Xiaojuan Xu Shuyong (Department of Chemistry, South China Normal University, GuangZhou,510631);Research Advancement of Polysaccharides[J];Guangdong Chemical Industry;2004-01
8 Sheng Jiarong; Zeng Linghui; Zai Chun; Cheng Chaoqu(Chem. Dept. Guangxi Teachers College, Nanning, Guangxi, 530001);THE EXTRACTION, ISOLATION ANDSTRUCTURE ANALYSIS OF POLYSACCHARIDS[J];Journal of Guangxi Teachers College;1999-04
9 Qin Chuanguang Ma Li Ding Yan Wang Weihong;Component Identification of the Red Pigment from Mockstrawberry Fruit by Paper-layer Chromatography[J];JOURNAL OF HUBEI POLYTECHNIC UNIVERSITY;1998-03
10 Tang Faqing et al(First affiliated Hospital, Changsha 410007);MORPHOLOGICAL OBSERVATION ON RHI2OMA COPIDIS AND ITS COMPLEX TO KILL NPC CELLS[J];JOURNAL OF HUNAN COLLEGE OF TRADITIONAL CHINESE MEDICINE;1996-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LI Tian-jin et al (Zhangjiakou Institute of Education,Zhangjiakou,Hebei 075000);Studies on the Extraction and Purification Techniques of Polysaccharides from Acathopanax senticosus[J];Journal of Anhui Agricultural Sciences;2009-17
2 LI Chang-yu1,AI Jun1,LEI Xiu-juan1,ZHANG Jun2(1.Institute of Wild Economic Animal and Plant of Science,China Academy of Agricultural Sciences,Zuojia,Jilin 132109,China;2.Dunhua Forestry Bureau,Dunhua,Jilin 133401,China);Research Progress on Relationship between Living Area and Drug Composition Content of Acanthopanax senticosus (Rupr. EtMaxim) Harms[J];Northern Horticulture;2009-12
3 LI Yan-hui,ZHANG Yan,LIU Zhi-lin (Parks and Gardens Administration of Baoding City,Hebei Province 071000,China);Biological characteristics and gardening application of Duchesnea indica[J];Hebei Journal of Forestry and Orchard Research;2006-03
4 Bai Hua,Fan Qingxia,Wang Liuxing,Wang Ruilin(Department of Oncology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China);The Research on the Effect of Yiliuning on MDA-MB-231,NCI-H520,A549 and Hela Cells[J];Journal of Basic and Clinical Oncology;2007-03
5 DIAO Bo,TANG Ying,LI De-zhong,et al.Department of Medical Laboratory,Wuhan General Hospital,Guangzhou Military Command,Wuhan Hubei 430070,China;Acanthopanacis Senticosi Polysaccharides Protects against Apoptosis of Hippocampal Neurons Induced by H_2O_2[J];Military Medical Journal of South China;2008-01
6 Han Xue Liu Anjun et al.;Comparation on preparation and biological function of polysaccharde from different sources[J];China Feed;2008-07
7 WANG DUAN-SHUN,LIN ZHONG-XIANG,YAN YU-XIN,HE DA-CHENG,LEI SI-JIN,ZHANG QI-HANG,AND WANG KUN-REN (Department of Biology,Beijing Normal University Beijing,China)(Department of Cell Biology,Beijing Institute for Cancer Research,Beijing,China);THE BIOLOGICAL EFFECTS OF SODIUM BUTYRATE ON CULTURED HUMAN STOMACH CANCER CELLS AND ESOPHAGEAL CANCER CELLS[J];Acta Biologiae Experimentalis Sinica;1985-02
8 DIAO Bo, TANG Ying, WANG Xiao-kun, DENG Hui-ling, WEN Ye. Department of Medical Experimentation, Wuhan General Hospital, Guangzhou Military Command, Wuhan 430070, China;A study on the antioxidative effect of acanthopanacis senticosi polysaccharides[J];The Journal of Practical Medicine;2008-07
9 QIN Sheng-ying, LIU Wen, ZHANG Yuan-yuan,CHEN Xiao-hui, LIAO Jia, BI Kai-shun(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China);Preliminary study on the anti-tumor effect of the extracts of four traditional Chinese medicines[J];Northwest Pharmaceutical Journal;2007-01
10 LIANG Wei,LIANG Ying,YING Hui-fan(Department of Etiology,Xianning College,Xianning Hubei 437100,China);Antibacterial Effect of Duchesnea Indica Focke[J];Journal of Xianning College(Medical Sciences);2005-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved