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《Beijing Medical Journal》 2003-05
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Significance of endostatin and VEGF expression in laryngeal carcinoma and vocal polyps

Zhang Lihong,Ge Yi,Wang Min,et al (Department of Otolaryngology,People’s Hospital,Peking University,Beijing 100044)  
Objective To explore the expressive significance of endostatin and vascular endothelial growth factor (VEGF) in laryngeal carcinoma and vocal polyps.Methods The surgical specimens from 48 laryngeal carcinoma and 20 vocal polyps patients were stained immunohistochemically for endostatin and VEGF expressions.Results ①High endostatin expression and positive expression of VEGF were found in 62.5%and 68.75%of laryngeal carcinoma specimens.higher endostatin expression and positive expression of VEGF were correlated with the development of cervical lymph node metastasis ( P =0.012);②There was no expression of VEGF in vocal polyps,the expression of endostatin was lower than that of laryngeal carcinoma.Conclusions The results of the study show that the VEGF and endostatin are significant predictors of prognosis in laryngeal carcinoma patients.
【CateGory Index】: R739.62
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