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《Beijing Medical Journal》 2004-05
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Clinical Study on the use of Sodium Valproate during perioperative period to prevent early postoperative seizure

Wang Yonggang,Zhao Jizong,Zhang Maozhi,et al (Department of Neurosurgery,Beijing Tiantan Hospital,Beijing 100050)  
Objective To evaluate the effect of sodium valproate (VPA) during perioperative period in preventing early postoperative seizure.Methods 60 patients with supertentorial disorders who had the history of epilepsy were involued.They were prescribed with sodium valproate before operation.After the blood concentrationoral of VPA reached the effective level,the operations were performed and it was given intravenously 30 minutes before the completion of operations and was maintained after the operation.Results Early postoperative seizure only appeared in two cases,which were due to low blood concentation.One patient had tardive tetter and one had abnormal liver function test.No neurological side-effect was observed.Conclusions It is very necessary to use the anticonvulsive drugs rationally during perioperative period.VPA is an effective and safe drug in preventing early postoperative seizure.
【CateGory Index】: R742.1
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1 WANG Wei-ming1,PENG Yue2,SUN Xiao-guang3,SU Quan-xin4 Instructor: PENG Jian-zhong3 1.Grade 2010 Postgraduate,Beijing University of Traditional Chinese Medicine;2.China-Japan Friendship Hospital;3.Beijing University of Traditional Chinese Medicine;4.Guangji Traditional Chinese Medicine Hospital,Beijing;Differentiation and treatment of adverse reaction by cooling blood and cultivating primordial qi method: A report of 2 proven cases[J];Shanghai Journal of Traditional Chinese Medicine;2012-08
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