The clinical study on the relationship between target organ damage and the reproducible patterns of ABPM

Wang Dexian, Zhao Wei, Sun Yanshu, et al (Department of Geratology, The First Hospital of Peking University, Beijing 100034)  

Objective To assess the association of a reduced nocturnal fall in blood pressure with more prominent taget organ damage. The nocturnal fall of blood pressure was established on the basis of two 24-hour ambulatory blood pressure monitoring(ABPM) sessions in a recent diagnosis of hypertension. Methods A more accurate definition of blood pressure pattern based on two concordant ABPMs was adopted. 137 patients showing reproducible dipping or non-dipping patterns were enrolled.The target organ damage of them were carefully examined. Results The patients were divided into two groups:The dippers(n=106) and non-dippers(n=31). There were differences between the dippers and non-dippers, such as left artrial-internal diameter and E/A(32.6±3.8 vs 35.7±4.0 and 1.1±0.34 vs 0.95±0.32, respectively, P0.05), There were also differences in the patterns of left ventricular hypertrophy and geometric remodeling, and there was more concentric remodelling in non-dippers than dippers(58.1% vs 37.7%, P0.05), and more left ventricular hypertrophy(25.8% vs 9.5%, P0.001). The common carotid artery intima-media thickness(IMT)and the prevalence of IM thickening were significantly greater in non-dippers than in dippers(P0.05). Conclusions Despite similar clinic and 48-hour BP values, never-treated hypertensive patients with a persistent non-dipper pattern hane showd a significantly greater extent of cardiac and artery structural alterations compared with a reproducible dipping pattern.

【Key Words】： Ambulatory blood pressure monitoring(ABPM) Blood pressure diurnal pattern Target organ
【CateGory Index】： R544.1

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