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《Beijing Medical Journal》 2008-03
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The killing effect of human Macrophage induced by Newcastle Disease Virus to Hep-2 tumor cells in Vitro

ZHANG Ping, PENG Jun (Department of ENT Section Affiliated Hospital of North China Coal Medical College, Tangshan 063000)  
Objective To study the antitumor activity of human Macrophage(Mφ) induced by Newcastle Disease Virus (NDV) and UV-inactivated NDV (NDV-UV) in vitro. Methods Peripheral blood mononuclear cells (PBMC) were purified via Ficoll-Paque from human peripheral blood and human Mφ were obtained with plastic-adhering method. The human Mφ stimulated with NDV and NDV-UV for 16 hours were acting as effect cells, and Hep-2 tumor cells were acting as target .The tumor-cytotoxic effects of human Mφwere detected by MTT method and further compared between induction of NDV and NDV-UV. Results The tumoricidal activity of human Mφ induced by NDV and NDV-UV was higher than non-induced group (P﹤0.01). The tumor-cytotoxic effects of human Mφ induced by NDV was stronger than NDV-UV group (P﹤0.01). Conclusions Both NDV and NDV-UV can promote tumoricidal activity of human Mφ in vitro, and the tumoricidal activities of NDV-stimulated human Mφ seem to be higher than that of NDV-UV stimulated ones.
【CateGory Index】: R739.65
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