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《Beijing Medical Journal》 2010-01
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The incidence and treatmeat of fatty liver in obese children with different status of glucose metabolism

LIU Xiu-qin,GONG Chun-xiu,HUANG Hui,et al(Department of Endocrinology,Beijing Children’s Hospital,Beijing 100045)  
Objective To compare the level of blood lipid,liver function and the incidence of non-alcoholic fatty liver and fatty hepatitis in obese children with different glycometabolism status,and to evaluate the therapeutic efficacy of metformin.Methods 132 obese children were chosen from Beijing Children’s Hospital,and were divided into three groups according to oral glucose tolerance test(OGTT) results.Group one:normal glucose metabolism.Group two: hyperinsulinaemia with lifestyle intervention(2A)or treated with metformin(2B).Group three:abnormal glucose metabolism.Results The incidence of fatty liver in three groups was 41.9%,65.9% and 86.3% respectively.The incidence of non-alcoholic fatty hepatitis was 35.5%,53.7% and 68.6% respectively(P 0.05).The improvement rate of fatty liver and fatty hepatitis was 38.5% and 54.5% in group one,31.3% and 30.7% in group 2A,82.4% and 64.2% in group 2B,68% and 60% in group three.Conclusions The incidence of fatty liver and fatty hepatitis steps up in the three groups.Metformin treatment is more effective than lifestyle intervention for patients with non-alcoholic fatty liver disease.
【CateGory Index】: R723.14;R725.7
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