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《Beijing Medical Journal》 2010-07
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Efficacy of Omeprazole on digestive tract hemorrhage in critical diseased children

LIU Ming-yue, ZHANG Qi, WANG Fei, et al (Department of Emergency, Children’s Hospital Affiated to Capital Institute of Pediatric, Beijing 100020)  
Objective To evaluate efficacy of Omeprazole for the treatment of digestive tract hemorrhage in critical diseased children. Methods Forty-two critical diseased children with digestive tract hemorrhage in ICU were randomly divided into two groups. The treatment group was treated with Omeprazole [0.7mg/(kg·d)] and the control group was treated with Cimetidine. The effective rate, the stop time of hemorrhage and the duration of stay were compared. Results Between the treatment group and control group, the effective rate was 95.24% and 66.67% respectively(P 0.01). The hemorrhage stop day was 2.6 days and 4 days. The hospital days was 11 days and 14 days. Mild adverse side reactions were present in 1 patient and disappeared after Omeprazole discontinuation. Conclusions Our data suggests that Omeprazole treatment is effective but without severe adverse reactions. Omeprazole treatment can shorten the hemorrhage time and hos- pital days.
【CateGory Index】: R720.597
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