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《Beijing Medical Journal》 2014-04
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Study on the of role of abnormal savda munziq on the antioxidant and fatigue effect in EAC tumor bearing mice

Ainiwaer·Aikemu;Abudureyimu·Yusufu;Dilinuer·Maimaitiyiming;Nuermaimai·Aimaiti;Zukereguli·wumaierniyazi;Dangming;Halmurat Upur;Department of Pharmaceutical Analysis, Xinjiang Medical University;;  
Objective To study the role of abnormal savda munziq on the anti-fatigue effect in EAC tumor-bearing mice. Methods 120 EAC solid tumor mice were randomly divided into high、medium、low dosage Abnormal savda munziq group, cyclophosphamide group, tumor group and normal control group. The climbing pole test was conducted in these mice to check their fatigue resistance ability 10 days later. 2. The tumor inhibition rate, spleen index, thymus index, liver index, SOD, MDA, GSH-PX index in serum were determined. 3. 120 EAC solid tumor mice were randomly divided into high、medium、low dose Abnormal savda munziq group, the verapamil group, tumor group and normal control group. The normobaric hypoxia tolerance to hypoxia in mice were observed 10 days later. Results The pole climbing time in the high, medium and low dosage Abnormal savda munziq group was prolonged by 35.87%(P 0.05), 75.79%, 26.27%,the serum SOD, GSH-PX content increased significantly(P 0.05), the content of MDA decreased(P 0.05) and hypoxia tolerance in mice was prolonged by 17.71%, 39.54% and 3.99%(P 0.05). The inhibition rates of the low and high Abnormal savda munziq group and the cyclophosphamide group were 46.34%, 60.98%, 38.86% and 49.73% respectively. This suggested that they had evident anti-tumor effect. Conclusion Abnormal savda munziq has antioxidant effect and play a role in anti-fatigue effect in EAC tumor-bearing mice.
【Fund】: 教育部长江学者和创新团队发展项目(编号:IRT0977);; 国家自然科学基金项目(81360668)
【CateGory Index】: R285.5
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