Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Blood Transfusion》 2013-05
Add to Favorite Get Latest Update

The influence of different anesthesia on the physiology,blood gas and hemorheology of rat

YOU Guoxing,WANG Ying,WANG Bo,YIN Yujing,ZHAO Lian,ZHOU Hong.Equally.Institute of Transfusion Medicine,Academy of Military Medical Sciences,Beijing 100850,China  
Objective To compare the influence of different anesthesia on parameters of physiology,blood gas and hemorheology,and standardize the model used for evaluating the blood substitutes.Methods A total of 16 Wistar rats were divided into 2 groups randomly according to the anesthesia,sodium pentobarbital intraperitoneal injection(S group) or urethane intramuscular injection(U group).The acting time was recorded and the physiological parameters were also evaluated every 5 min till 40 min after operation.Then blood was withdrawn to assess the blood gas,blood cells and hemorrheology parameters.Results The times needed for S group and U group were 3.67 min and 31 min respectively,showing that the former came into effect much faster than the latter(P 0.01).Compared with S group,the U group decreased the mean arterial pressure(5,15,30,35 and 40 min,P 0.05),the systolic pressure(35 and 40 min,P 0.05),the diastolic blood pressure(15,30 and 35 min,P 0.05),the pulse pressure(40 min,P 0.05) and the body temperature(expect for 5 min,P 0.05) significantly.And 40 min after the operation,there were significant higher haematocrit(P 0.05),lower arterial pH value(P 0.01) and plasma viscosity(P 0.05) in U group than those in S group.Conclusion The anesthesia via urethane intramuscular injection should be chosen cautiously because of its influences on rats' physiology,blood gas and hemorrheology parameters.
【Fund】: 国家自然科学基金面上基金项目(31271001);; 国家高技术研究发展计划主题项目(2010AA021902);; 北京市科委首都市民健康项目培育(Z121100005312014)
【CateGory Index】: R614
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 FENG Jian-hua1,2,YOU Guo-xing1#,WANG Ying1,KAN Xue-mei1,ZHAO Lian1,ZHOU Hong1 (1.Institute of Transfusion Medicine,Academy of Military Medical Sciences,Beijing 100850,China;2.College of Environment and Chemical Engineering,Yanshan University,Qinhuangdao 066004,China);Factors that affect the preparation of a severe hemorrhagic shock model of Wistar rats[J];Military Medical Sciences;2011-08
2 Zhao Lian,You Guoxing,Xu Jing,et al Institute of Transfusion Medicine,Academy of Military Medical Science,Beijing 100850;Preparation of Different viscosities Plasma Expander and Their Application in Hemorrhagic Shock[J];Chinese Journal of Microcirculation;2008-02
Chinese Journal Full-text Database 10 Hits
1 SHA Ai-long(College of Life Science,Shandong Normal University,Jinan 250014,China);The Argumentation of Three Anesthetics on the Physiology Character of Animal Tissue and Organ[J];Journal of Beijing Union University(Natural Sciences);2007-03
2 SHA Ai-long1,AJI Nuera-mina1,AI Hong-bin2(1.College of Animal Science,Tarim University,Key Laboratory of Animal Husbandry Science and Technology of Xinjiang Production and Construction Corps,Alar,Xinjiang 843300,China; 2.College of Life Science,Shandong Normal University,Jinan 250014,China);Comparative Research on the Effects of Three Anesthetics on the Blood Pressure,Heart Rate and Respiration in Rabbits[J];Journal of Beijing Union University(Natural Sciences);2011-03
3 YOU Guoxing,ZHAO Lian,CHEN Gan,WANG Ying,LU Mingzi,LI Penglong,ZHANG Jingang,ZHOU Hong.Institute of Transfusion Medicine,Academy of Military Medical Sciences.Beijing 100850;Effects of different red blood cell transfusion time on hemorrhagic shock resuscitation in rat model[J];Chinese Journal of Blood Transfusion;2012-02
4 PENG Yong,LIU Zhe,WU Yun-hui,JIANG Bin,LIU Ying-jie,SUN Man,ZHANG Yan-xia (Department of Biomedicine Engineering,Yanshan University,Qinhuangdao 066004,China);The anesthetic effects of Urethane on adultcrucian carp Carassius auratus[J];Journal of Dalian Ocean University;2011-06
5 XIE Xiao-li1,XU Yue-jin1,XIAO Zhong-ju2,ZHOU Ling-hong1 1School of Biomedical Engineering,2Shool of Basic Medical Sciences,Southern Medical University,Guangzhou 510515,China;Monitoring of anesthetic effect based on auditory response time[J];Journal of Southern Medical University;2011-11
6 SUN Xu-hua1,LI Min2,WANG Li3,et al(1.Department of Orthopedics,the Affiliated Hospital of Guilin Medical College,Guilin 541004,China;2.Department of Anesthesia,the Affiliated Hospital of Guilin Medical College,Guilin 541004,China;3.Department of Hepatobiliaty,the Affliated Hospital of Guilin Medical College,Guilin 541004,China);Comparison of effects of several anesthetic in rabbit spinal surgery[J];Jilin Medical Journal;2011-02
7 LI Bo1,JIAO Jian-lin1,LU Yu-hui2,LIU Hong-lian1(1.Laboratory Animal Center of Kunming Medical University,Kunming 650031,China,2.Panlong District Chinese Medical Hospital of Kunming,Kunming 650051,China);The Narcosis for Diabetes Mellitus Peripheral Nerve Injury Rat[J];Science & Technology Information;2008-17
8 Zheng Guoqiang Ai Hongbin( College of Life Science,Shandong Normal University,250014,Jinan,China);EFFECTS OF THREE ANAESTHETICS ON THE PHYSIOLOGICAL CHERISTERISTICS OF ISOLATED HEART OF TOAD[J];Journal of Shandong Normal University (Natural Science);2005-04
9 CHEN Kui, LIU Wan_xiu, XIE Yang_min, ZHENG Feng_ren(Department of Surgery, Medical College of Shantou University, Shantou\ 515031, China);Comparison of Anesthetic Effect of Two Kinds of Anesthesia in Experimental Surgery of Dog[J];Laboratory Animal Science and Administration;2004-04
10 ZHAN Hong-wei,QIU Ze-wen,LI Hui-ling,DONG Jian-yi,WANG Ai-guo,WANG Fu-jin,WANG Jing-yu(Laboratory Animal Center of Dalian Medical University,Dalian 116044,China);Anesthetic Effects of Three Kind of Narcotic Drugs on Mice[J];Laboratory Animal Science;2012-04
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 XIA yan-qiu~1 ,ZHU qiang~2 ,Wang Zhi-jun~1 (1. College of Bioscience and Biotechnology of Yangzhou University, Yangzhou 225009,China; 2. Huaihai institute of Technology, Lianyungang 222005,China);Warning of ethyl carbamate in Chinese rice wine[J];Liquor-making;2004-03
2 Gong TF,Fang CY,Chen W,Wang PN.Department of Orthopaedics,Taihe Hospital Affiliated to Yunyang Medical College,Shiyan 442000,Hubei Province,China;Physiochemical properties of alginate in tissue engineering research and its clinical application[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-18
3 GAO Nian-fa,BAO Ju-hua(Tianjin Key Laboratory of Industrial Microbiology,College of Bioengineering,Tianjin University of Science and Technology,Tianjin 300222,China);Research advancement of ethyl carbamate[J];China Brewing;2006-09
4 Zhang Qnglin;et al., (Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences (Beijing 100850));Short-term Test Study of Urethan-induced Lung Tumor in Mice[J];;1994-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved