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《Chinese Journal of Blood Transfusion》 2013-05
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The influence of different anesthesia on the physiology,blood gas and hemorheology of rat

YOU Guoxing,WANG Ying,WANG Bo,YIN Yujing,ZHAO Lian,ZHOU Hong.Equally.Institute of Transfusion Medicine,Academy of Military Medical Sciences,Beijing 100850,China  
Objective To compare the influence of different anesthesia on parameters of physiology,blood gas and hemorheology,and standardize the model used for evaluating the blood substitutes.Methods A total of 16 Wistar rats were divided into 2 groups randomly according to the anesthesia,sodium pentobarbital intraperitoneal injection(S group) or urethane intramuscular injection(U group).The acting time was recorded and the physiological parameters were also evaluated every 5 min till 40 min after operation.Then blood was withdrawn to assess the blood gas,blood cells and hemorrheology parameters.Results The times needed for S group and U group were 3.67 min and 31 min respectively,showing that the former came into effect much faster than the latter(P 0.01).Compared with S group,the U group decreased the mean arterial pressure(5,15,30,35 and 40 min,P 0.05),the systolic pressure(35 and 40 min,P 0.05),the diastolic blood pressure(15,30 and 35 min,P 0.05),the pulse pressure(40 min,P 0.05) and the body temperature(expect for 5 min,P 0.05) significantly.And 40 min after the operation,there were significant higher haematocrit(P 0.05),lower arterial pH value(P 0.01) and plasma viscosity(P 0.05) in U group than those in S group.Conclusion The anesthesia via urethane intramuscular injection should be chosen cautiously because of its influences on rats' physiology,blood gas and hemorrheology parameters.
【Fund】: 国家自然科学基金面上基金项目(31271001);; 国家高技术研究发展计划主题项目(2010AA021902);; 北京市科委首都市民健康项目培育(Z121100005312014)
【CateGory Index】: R614
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