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《Chinese Journal of Blood Transfusion》 2013-08
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Polymorphism of HPA-21 in Han blood donors in Guangzhou,China

ZHOU Haojie;WANG Chuanxi;NIE Yongmei;Guangzhou Blood Center;  
Objective To study the polymorphism of human platelet antigen(HPA)-21 in Han blood donors in Guangzhou,China.Methods The sequence-specific primers(SSP) for HPA-21 were newly designed.A total of 200 Han voluntary platelet donors in Guangzhou were genotyped for HPA-21 by using a SSP method and verified by DNA-sequencing.Results Of all the 200 Han blood donors,198 cases were genotyped homozygous HPA-21a /-21a and 2 individuals were HPA-21a /-21b heterozygous by SSP,which were verified by DNA-sequencing.Gene frequencies of HPA-21a and HPA-21b in Han blood donors in Guangzhou were 99.50% and 0.50% respectively,which fit Hardy-Weinberg equilibrium.The chance of incompatibility in random platelet transfusion was 0.99% for HPA-21.Conclusion Gene frequencies of HPA-21 in Han blood donors in Guangzhou were obtained,which provided a basis to establish the local platelet donors database and improve HPA-matched platelet transfusion.
【Fund】: 广东省医学科研基金项目(B2013345)
【CateGory Index】: R394
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