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《白求恩医科大学学报》 1990-04
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EFFECT OF PANAXADIOL SAPONIN ON LIPlDPEROXIDE OF TISSUES IN RATS WITH ENDOTOXIC SHOCK

Liu Yuanyuan, et al(Department of Infectious Diseases)  
In order to explore the protective effect of panaxadiol saponin against endotoxic shock, experimental models were duplicated by injection of semifinished coliendotoxin into the abdominal cavity in rats. Sixty-six rats were randomly divided into 2 groups:an endotoxic shock group (ES) and a panaxadiol saponin therapeutic group(PT). Sixteen hour survival rate in PT group was significantly higher than that in ES group (P0.05) , and content of lipidperoxide in the liver, lung and kidney was lower in the PT group than that in the ES group (P0.05). These results showed that panaxadiol saponin has a protective effect against endotoxic shock in rats through decreasing lipidperoxide in the tissues to stabilize the cytomembrane.
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