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《白求恩医科大学学报》 1993-02
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EFFECT OF SOYASAPONIN AND GINSENOSIDE (STEMLEAVE SAPONIN) ON SOD AND LPO IN DIABETIC RATS

Wang Yinping, Wu Jiaxiang, Zhang Fenglan, Wang Xinrui (Dept. of Pathol, Basic School of Medical Sciences)  
In this investigation. 33 male Wistar rats (weighing 200-225g) were divided into 4 groups: the normal control, the diabetic control, diabetes+ GS and diabetes+ SS. 55mg/kg of streptozocin was intravenously injected to induce diabetes in rats. 150 mg/kg · day of GS and 10mg/ kg· day of SS were given P. O. for 20 weeks to the diabetic rats respectively. The effects of GS and SS on the levels of blood sugar, SOD and LPO were observed for the purpose of finding some theoretic basis for extensive clinical use to combat free radical injuries and in the public health field. The evidently increased levels of blood sugar and LPO decreased, and the evidently decreased levels of SOD increased after administration of GS and SS, suggesting that GS and SS can protect the diabetic rats from free radical injuries to some extent.
【CateGory Index】: R587.1;;R966
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