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《Journal of Norman Bethune University of Medical Science》 1998-05
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Electron microscopic observation and Ca~(2+) analysis on protective effect of ginsenoside from fruit on myocardium of hemorrhagic shock in dogs

Li Ying 1,Cui Xinming 1,Pan Li 1,Li Zhenbao 1,Ji Chongde 2,Du Kuiqin 3 (1\ Dept.of Electron Microscopy;2\ Dept.of General Surgery,The Third Clinical College;3\ Dept.of Pathophysiology)  
Objective:In this paper,protective effect of ginsenoside from fruit on myocardium in hemorrhagic shock dogs was studied.Methods:Sixteen mongrel dogs were equally divided into hemorrhagic shock group (HS,caused by artery bleeding and arterial blood pressure to 5.3 kPa which was maintained for 5 h) and hemorrhagic shock ginsenoside group (HSG,ginsenoside from fruit was IV injected into dogs at 15 mg/kg BW before bleeding and other treatment was as same as HS).Survival rate of dogs after bleeding for 5 h and changes of ultrustructure and Ca 2+ in myocardium of dogs were observed.Results:In comparison with HS,①Survival rate of dogs in HSG after bleeding for 5 h significantly increased, P 0 05;②Ultrustructural damages,e.g,sarcolemma myofibrils,sarcoplasmic reticulum,mitochondria and intercalated disc of myocardium in dogs of HSG markedly decreased.③Ca 2+ contents of sarcoplasmic reticulum increased and mitochondria decreased in myocardium of dogs of HSG.Conclusion:These results suggest that ginsenoside from fruit possesses the protective effect on myocardium in hemorrhagic shock dogs.
【CateGory Index】: R285.5
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