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《JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE》 1999-04
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Effects of traditional Chinese medicine of anti thrombosis on thrombosis and the activity changes of plasma t PA and PAI in mice

Liu Guoxun 1,Wu Tie 2,Chen Zhidong 2,Yang Qin 1,Ling Guangxin 1 (1\ Research Lab.of Blood diseases Affiliated Hospital of Guangdong Medical College,Zhanjiang 2\ Department of Pharmacology,Guangdong Medical College,Zhanjiang)  
Objective:To investigate the effects of Composite Salviae Miltiorrhizae Injection,Ligustrazine Injection and the anti thrombosis capsule on thrombosis and plasma tissue plasminogen activator (t PA) and it′s inhibitor (PAI) in the thrombosis model of mice.Methods:Composite Salviae Miltiorrhizae Injection,Ligustrazine Injection and the anti thrombosis capsule were given to mice in different groups for 7 days respectively.Thrombosis was induced in mice by Carrageenan.The plasma t PA and PAI activity were detected by chromogenic substrate analysis.Results:The average thrombosis length of tail in the group of Salviae Miltiorrhized and the group of anti thrombosis capsule were significantly shorter than the length in the group of thrombosis control ( P 0 05).The plasma PAI activity in the groups of Salviae Miltiorrhizae and anti thrombosis capsule were lower than that in the group of thrombosis control ( P 0 05).Conclusion:Salviae Miltiorrhizae and anti thrombosis capsule can reduce thrombosis in mice.The mechanism might be associated with reducing the release of PAI.
【Fund】: 广东省卫生厅科研课题
【CateGory Index】: R285.5
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【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 LI Zhi gang, ZANG Lei, LIU Song qing (Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Anti-apoptosis effect of ligustrazine on the apoptosis of PC12 cells induced by dopamine[J];Acta Academiae Medicinae Militaris Tertiae;2003-18
2 ;Clinical Observation of 47 Cases of Buerger Discase Treated by Combination of Chinese Medicine and West Medicine[J];Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology;2004-02
3 WAN Li-hong,FANG Zhi-ping,WANG Zheng-rong West China School of Basic Medical Sciences and Foresic,Sichuan University,Chengdu 610041,China;EFFECTS OF DA CHUANXIONG FANG EXTRACT ON INTRACELLULAR NITRIC OXIDE OF NEUROGILA[J];West China Journal of Pharmaceutcal Sciences;2002-04
4 ZHAO Xiqing,JI Xunming,LING Feng,et al.Department of Neurosurgery,Tangshan People's Hospital,Tangshan,Hebei Province 063000,P.R.China;Clinical Curative Effect of the Unity of Chinese Traditional Medicines Against Cerebral Ischemic/Reperfusion Injury[J];Journal of Clinical Radiology;2009-06
5 WU Yu kun,SUN Xiu ling,WU Yu ling (Linyi Medical College,Linyi China,276002);THE CURATIVE EFFECT OF NAOMAITONG CAPSULES ON THE CONTENT OF NITRIC OXIDE IN THE SERUM OF PATIENTS WITH ACUTE CEREBRAL INFARCTION[J];Journal of Linyi Medical College;2002-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Shu Zhirong, Zhang Qiuye, Dong Yanhua, et al Department of Pediatric, Qingdao Medical College, Qingdao 266003;THE CHANGE OF ERYTHROCYTE IMMUNOLOGIC FUNCTION IN SIMPLE NEPHROTIC SYNDROME IN CHILDREN[J];;1997-03
2 Du Yumao (shaanxi College of TCM, Shaanxi);Clinical and Experimental Researches on Chronic Kidney Failure Treated with Zhenwu Decoction[J];;1991-04
3 Yang Sumei, Ru Xiaoguang (Department of Changzhi Medical College);The Relationship Between Smoking, Drinking, Fat and Hypertension[J];Journal of Changzhi Medical College;2000-04
4 HU San-Jue,TIAN Qiao-Lian,GU Jian-Wen,SHA Jian-Hui,ZHAO De-HuaYAN Pei-Song,ZHU Xin-Sheng and PEI Qi-YingDepartment of Physiology Department of Pharmacology Department of Pathology Department of Medical Laboratory,Xijing Hospital;A new in vivo animal model of thrombosis formation[J];Journal of The Fourth Military Medical University;1993-01
5 GUAN Jian-xun, ZHENG Kai-jun. (Department of Pediatrics,the Huaqiao Hospital of Shiqi,Zhongshan 528400,China);Effect of Baoshenkang in treatments of nephritic syndrome with high coagulation state[J];Journal of Branch Campus of the First Military Medical;2003-02
6 ;36 Cases of Treating High Blood Coagulation in Nephrotic Syndrome with Blood-Quickening and Stasis-Dispersing Chinese Herbs[J];Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology;2001-06
7 LIU Xiao-gang, LIU Su-yan (Department of Nephrology, The Second Clinical College, Harbin Medical University, Harbin 150086, China);Investigation on effect of Huang Kui in experimental nephritic syndrome and its mechanism[J];Journal of Harbin Medical University;2005-04
8 Guan Deming et al(Institute of Cardiovascular Disease,The First Affiliated Hospital);Effects of Smoking and Drinking on Hemorrheology in Patients with Essential Hypertension[J];JOURNAL OF HARBIN MEDICAL UNIVERSITY;1998-04
9 SUN Bei-hua et al (Linyi Municipal Peple's Hospital,Linyi 276003,China);Risk Factors of Mycardial Infarction in Young People[J];Journal of Heze Medical College;2001-01
10 YANG Zhengquan, WANG Peishan. Tianjing First Hospital, Tianjing 300010, China;Relationships between cigarette smoking, alcohol consumption and cerebral hemorrhage[J];CHINESE JOURNAL OF DISEASE CONTROL AND PREVENTION;1999-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 MAO Liming,CHENG Xiaoxia,YIN Zijie,et al Department of Nephrology,Hangzhou hospital of TCM,Hangzhou(310007);The Experiment Study of Yi Shen Tiao Jing Fang's Kidney Protection Effect on Female Hypogoandism Rats Induced by Tripterygium Wilfordii Ployglycosidium[J];Chinese Journal of Integrated Traditional and Western Nephrology;2008-04
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