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《JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE》 2000-02
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Studies on the elimination of resistance plasmid from P.aeruginosa in vitro and vivo with Lonicera japonica

Wang Yun,Yu Jun,Xiao Yang,Cheng Li,Guan Xianzhi (Department of Pathogenobiology) 〔  
? Objective:To explore eliminating effect of Lonicera japonica on R plasmid from P.aeruginosa.Methods:Replica plating and counting of colonies resisting to antibiotics were carried out in vitro.Germ free mice in intestine were orally inoculated with P.aeruginosa,then water decoct agent of Loponica japonica was given orally in 2 mg per mouse,and same dosage of Loponica japonica were repeatedly given 24 h late.Eliminant of P.aeruginosa was identified by replica plating and colony counting after 48 h. Results :No strain of eliminated R plasmid was obtained in vitro,but there were 80 strains in vivo,and elimination rate was eight percent (8%).Conclusion:Water decoct agent of Loponica japonica showed stronger effect on elimination of resistance plasmid from P.aeruginosa in vivo.The elinination rate was eight percent (8%). 〔
【CateGory Index】: R285.5
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