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《白求恩医科大学学报》 2001-02
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Study of anti-aging and anti-dementia effects of Rhodosin on aging rats and experimental dementia rats

JIANG Wen-hua,MENG Xiao-ting,HAO Li-ming,CUI Li,DONG Zhi-yong,WANG Shu-lan (Department of Histology and Embryology,School of Basic Medical Sciences,Jilin University,Changchun 130021 China) [  
Objective:To discuss the effects of Rhodosin,the extractant of medical plants named Rhodiola Sachinonsis A.Bor,on aging rats and the model rats of Alzheier′s disease (AD).Methods:Step down and water maze tests were used to determine the content of acetylcholine (Ach) and the activity of acetylcholine transferase (ChAT) of hippocampus,lipid peroxide (LPO) and activity of superoxide dismute (SOD) of the cerebral cortex,and cerebellar cortex and spinal cord were observed respectively.At the same time,the general light microscope and eletron microscope were used to observe the changes in morphology.Results:The Rhodosin as an antioxidant could enhance the content of Ach and the activity of ChAT,reduce the formation of LPO,and increase activity of SOD.The Rhodosin could facilitate metabolism,enhance activity,and inhibit degeneration of aging rat cells.Conclusion:Rhodosin had obvious anti-aging effects on aing rats and also had preventive,protective,anti-dementia effects on experimental dementia.[
【Fund】: 吉林省科委资助!项目 (970 5 5 9- 3)
【CateGory Index】: R285
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