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《Journal of Norman Bethune University of Medical Science》 2001-02
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Change of neuropeptide Y in plasma in chronic renal failure patients and the effects of Astragalus on it

CUI Ming-ji 1,XU Xue-ming 1,ZHANG Rui 2 (1 Department of Nephrogy,First Hospital,Jilin University,Changchun 130021 China; 2\ The People′s Hospital of Jilin province) [  
Objective:To study the change of Neuropeptide Y (NPY) plasma and its clinical significance and the effects of Astragalus on NPY in plasma in chronic renal failure patients.Methods:Radioimmunoassay was used to measure plasma concentration of NPY.Results:①The plasma concentration of NPY in CRF patients was significantly higher than that in healthy group,and the plasma concentration of NPY in uremia patients was significantly higher than that in nitremia patients.②The plasma concentration of NPY was positively correlated with the serum value of CRE and the level of MAP in CRF patients.③After Astraglus treatment for 3 weeks,the level of NPY in plasma was significantly decreased in experiment group,but in control group,there was no significant change.Conclusion:The disturbance in synthesis,secretion or metabolism of NPY occurred in CRF patients,which significantly correlates with the occurrence and development of CRF.Astraglus can influence the NPY in plasma in CRF patients,so as to improve the renal function. [
【CateGory Index】: R692.5
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