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Comparative study of effects of Ginsenosides,Panaquilons and Eleutherosides on isolated working heart

CAO Xia 1,GAO Yu fei *,LI Hong 1,YANG Hong 1,YANG Shi jie 1,DU Xue rong 2 (1 Dept.of Pharmacology,School of Basic Medical Sciences,Jilin University,Changchun 130021 China; 2\ Department of Chinese Traditional Medicine,China Japan Union Hospit  
Objective:The experiment was used to observe hemodynamic effects of Ginsenosides (GinS), Panaquilons (PQS) and Eleutherosides(ASS) on isolated working rat heart. Methods:Isolated working heat of Wistar rats was observed, and six parameters including HR, AP, LVSP, ±dp/dt max and LVEDP were taken as indexes. Results:Three medicines marked negative inotropic action, made decline in AP, LVSP,±dp/dt max and rise in LVEDP as effects of verapamil. Conclusion:Study of comparison shows that GinS, PQS and ASS all reduced the myocardial contractility, but effect of GinS is most significant, the next is PQS, That of ASS is weaker. [
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