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Effect of Aralosides on rat hemodynamics

GE Jing yan, GUO Chun yao,ZHAO Chun yan,ZHANG Xue xin (Dept.of Physiology,School of Basic Medical Sciences,Jilin University,Changchun130021 China)  
Objective:To study the effect of Aralosides on rat cardiac function.Methods:Left ventricular systolic pressure(LVSP),left ventricular end diastolic pressure(LVEDP),maximal rising and falling rate of ventricular pressure(±dp/dt max ) were recorded with 4 channel polygraph and the hemodynamics of Aralosides(5,10,20 mg/kg) was observed.Results:After injected Aralosides,LVSP,absolute value of ±dp/dt max increased significantly,while LVEDP decreased. Aralosides(5,10,20 mg/kg) could increase +dp/dt max from (318±57),(311±50),(325±60)kPa/s before administration to (381±79),(441±58),(464±61) kPa/s after administration and decrease -dp/dt max from (-251±61),(-261±42),(-255±47)kPa/s before administration to (-317±55),(-333±42),(-330±46)kPa/s after administration,respectively.Conclusion: Aralosides can induce a dose effect positive inotropic action on myocardium.
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